Effective Veterinary API Tylosin Cas 1401-69-0 for Animal Growth Promotion

Product Description

Tylosin Cas 1401-69-0 Factory Pharmaceutical Chemicals manufacturer with top quality from China !

COA of cas 1401-69-0 Tylosin

Properties, Uses and Production Process of Tylosin antibiotic Tylosin is a kind of macrolide antibiotics commonly used for animal use in China, also known as Tannon and tylocin, which can be extracted from Streptomyces florii of actinomycete by fermentation, and has three forms of tylosin alkali, phosphate and tartrate. Similar to erythromycin in antibacterial spectrum, gram-positive bacteria and some gram-negative bacteria, mycoplasma, vibrio, coccidia, spirochetes, etc. have inhibitory effect on mycoplasma, but gram-positive bacteria is not as effective as erythromycin. This product is characterized by strong effect on mycoplasma, is one of the strongest anti-mycoplasma drugs in macrolides. As a feed additive, widely used in the feed of chickens, pigs, cattle, sheep, fish, shrimp and other animals, can promote the growth of livestock and poultry, improve the feed utilization rate. Mainly used for prevention and control of chicken, Turkey and other animals mycoplasma disease; Vibrio dysentery and infectious pleural pneumonia of pigs are also used for enteritis, pneumonia, mastitis and endometritis caused by sensitive bacteria. The effect of subcutaneous injection is better than that of oral administration in the treatment of chronic respiratory disease of chicken. In addition, tylobactin phosphate is also used as a growth-promoting medicinal feed additive for cattle, pigs and chickens. There is cross-resistance between this product and erythromycin. Eli lilly in 1962 successfully developed the tylosin and to market, it is mainly used for feed additives and animal treatment, it can obviously promote the growth of livestock and poultry feed utilization, mainly exists in the form of wessing alkali in the body, in the body can be combined with prokaryotic ribosomes, hinder the amino acid added to peptide synthesis, thus inhibiting infection mycoprotein biosynthesis, Strong tissue penetration, fast oral absorption, wide distribution in tissues (the highest amount is generated in lung, liver, kidney, spleen and gallbladder), high bioavailability, rapid effect, long time to maintain the effective antibacterial concentration, fast excretion after drug withdrawal, less residue, high safety. Accurate active ingredients, wide safety range, low toxicity. It is stable in nature and is not easy to be destroyed by environment, diluents and feed. The conventional preparation process of feed has little influence on its effective components. Tallosin has a good growth promoting effect, continuous low dose, not only can prevent disease, but also can significantly promote animal growth, shorten the feeding cycle. Tallosin is a special antibiotic for livestock and poultry, which avoids the problem of cross resistance of antibiotics common to human and livestock. Bioactivity Tylosin is Chemicalbook a antibiotic macrolide for veterinary use, is the product of Streptomycesfradiae. Tylosin has high antibacterial activity against Gram-positive bacteria. Tylosin is a feed additive widely used to promote animal growth. Tylosin is used to treat bacterial dysentery and respiratory diseases in poultry, pigs and cattle. Targets for Antibiotic in vitro study Tylosinexertsantibacterialeffectsbybindingto23SrRNAofthebacterialribosomal50Ssubunit Tylosinalsoprevents GrowthofGram - negativestrains withMICsof64 mu g/mL, 32 mu g/mL, 512 mu g/mLand1 mu g/mLforM haemolytica11935, p. ultocida4407, e.c. with our fabrication: oliATCC 25922andE.coliAS19rlmAI,respectively. In vivo study Tylosin(10-500mg/kg; Which) generallysuppressestheelevatedTNF - alpha beta levelsandincreasestheIL andIL - 1-10 levelsinthelipopolysaccharide (LPS) - treatedanim als.AnimalModel:Balb/Cmice(2-3monthsold,20-25g)Dosage:10mg/kg,100mg/kg,500mg/kgAdministration:SubcutaneousinjectionResul T: ReducedtheelevatedTNF - alpha beta inLPS andIL - 1 (250) including g - treatedmicebutincreasedtheirIL - 10 levels. Purpose Used as an antibacterial drug .