China Pharma Pure Powder manufacturer

Biltricide Schistosomiasis Praziquantel Cas 55268-74-1 USP BP standard

Product Details:
Place of Origin: Xi'an ,China
Brand Name: Wango
Certification: ISO 9001, USP, BP
Model Number: WG-0019
Payment & Shipping Terms:
Minimum Order Quantity: 1 kilogram by Express
Price: FOB price USD 118-128/Kilogram or Can be Negotiable
Packaging Details: 1kg with double plastic container inside/Aluminum foil bag ; 25kg with double plastic container inside/Fiber drum outside.Or as your request.
Delivery Time: 3-5 working days
Payment Terms: L/C, T/T, Western Union, MoneyGram
Supply Ability: 1000kilogram 0ne month

Detail Information

Function: Kill Schistosoma Stock: 1000 Kilogram
Name: Biltricide Cas: 55268-74-1
High Light:

Biltricide Schistosomiasis Praziquantel

,

USP Schistosomiasis Praziquantel

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BP Schistosomiasis Praziquantel

Product Description

Praziquantel USP 39 grade 99% Powder antiparasitic 2000 kilogram fresh stock with lowest price !

 

 

Biltricide Schistosomiasis Praziquantel Cas 55268-74-1 USP BP standard 0

 

Specification

 

Items of Test

Standard

Result of Test

Descriptions

White or partically white crystalline powder

conforms

Melting point

136-142°C

137-138°C

Identification

Consistent with the IR spectrum for reference standard

Conforms

Loss on drying

≤0.5%

0.1%

Residue on ignition

≤0.1%

0.02%

Phosphate

≤0.05%

<0.05%

Heavy metal

≤0.002%

<0.002%

Related substances

A≤0.2%

B≤0.2%

C≤0.2%

0.06%

0.06%

ND

Residual solvent

Ethanol ≤5000ppm

Chloroform ≤60ppm

45ppm

ND

Assay

98.5%-101.0%(dried substance)

100.5%

 

Composition

The main ingredient of the preparation is praziquantel.

 

Character

Praziquantel tablets: White tablets.

 

Indications

This product is suitable for all kinds of schistosomiasis, clonorchiasis, paragonimiasis, gingeriasis, tapeworm disease and cysticercosis.

 

specifications

Praziquantel tablets :(1) 0.2g; (2) 0.6g.

 

Usage.

Praziquantel tablets:

 

1. Treatment of fascidiasis:

 

(1) schistosomiasis: all kinds of chronic schistosomiasis with a total dose of 60mg/kg 1-2 day therapy, 2-3 times a day between meals. The total dose of acute schistosomiasis was 120mg/kg, 2-3 times a day for 4 days. Body weight over 60kg is calculated as 60kg.

 

(2) clonorchiasis: the total dose was 210mg/kg, 3 times a day for 3 days.

 

(3) Paragonimiasis: 25mg/kg, 3 times a day, for 3 days.

 

(4) Ginger pipeworm disease: 15mg/kg, one dose.

 

2, treatment of tapeworm disease:

 

(1) Beef and pork tapeworm disease: 10mg/kg, morning meal, 1 hour after taking magnesium sulfate.

 

(2) Hymenococcus pumilis and diphyllobothriasis lateriana: 25mg/kg, oral dose.

 

3, the treatment of cysticercosis: a total dose of 120-180mg/kg, 3-5 days, 2-3 times a day.

 

Clinical application and guidelines

Wei Xiaolong and Tan Ruibin et al. analyzed the clinical efficacy and side effects of albendazole tablets and praziquantel tablets in the treatment of liver fluke, and concluded that albendazole tablets and praziquantel tablets had similar clinical efficacy in the treatment of liver fluke, but albendazole tablets had fewer adverse reactions and higher safety, and could be rationally selected according to the actual situation in clinic. (electronic journal of modern medicine and health research,2018,2(13):73-74)

 

Adverse reactions

1, systemic damage: fatigue, limb pain, eosinophilia, in addition to the product caused by anaphylactic shock reported in the literature.

 

2. Cardiovascular system: palpitations, chest tightness, ECG showed T wave changes and external contraction, supraventricular tachycardia, atrial fibrillation.

 

3. Digestive system: nausea, abdominal pain, diarrhea, elevated transaminase, gastrointestinal bleeding.

 

4, skin and accessories: rash, itching, allergic purpura.

 

5. Nervous system: dizziness and headache.

 

6, other: induced mental disorders.

 

Taboo

1. Ophthalmic cysticercosis patients are prohibited.

 

2. Do not use in patients allergic to this drug or pharmaceutical excipients.

 

3, prohibit the simultaneous application of cytochrome P450 strong inducer, such as rifampicin.

 

Matters needing attention

1, the treatment of parasitic parasites in the tissue such as schistosoma, pneumofluke, cysticercosis, because the worm body is killed after the release of a large number of antigen substances, can cause fever, eosinophilia, rash, and sometimes cause anaphylactic shock, must be observed.

 

2, cysticercosis patients need to be hospitalized, and supplemented by the prevention and treatment of brain edema and reduce high cranial pressure (application of dexamethasone and dehydrating agent) or the prevention and treatment of epileptic status of the treatment measures, to prevent accidents.

 

3, combined with eye cysticercosis, surgical removal of the insect body must be first, and then drug treatment.

 

4. Use with caution in patients with serious heart, liver and kidney disease and those with a history of mental illness.

 

5. People with obvious nervous system reactions such as dizziness and drowsiness should not drive or operate machinery during treatment or within 24 hours after withdrawal.

 

6, cysticercosis in the removal of tapeworm, recessive cysticercosis except, so as to avoid accidents.

 

7. This drug can aggravate the central nervous system lesions caused by schistosomiasis, so it should not be given to patients with a history of epilepsy and/or other underlying central nervous system symptoms, such as cysticercosis subcutaneous nodules.

 

8. Patients receiving rifampicin and in urgent need of parasitic drug treatment should consider using other preparations for treatment. However, if treatment with praziquantel is necessary, rifampicin should be discontinued for 4 weeks before administration. Rifampicin therapy can be resumed 1 day after completion of praziquantel therapy.

 

9. Medication for pregnant and lactating women: Lactating women should not breastfeed during the medication period until 72 hours after withdrawal.

 

Drug interaction

Drug interactions may occur if used in conjunction with other medications. Consult your physician or pharmacist for details.

 

Pharmacological effects

This product is effective to schistosoma, tapeworm, cysticercosis, clonorchis sinensis, pneumofluke, ginger chip. It has two main pharmacological effects on the worm:

 

1. Spasmodic paralysis is caused by tonic contraction of insect muscles. The tension of schistosomiasis increased only 20 seconds after exposure to low praziquantel concentration. When the concentration of praziquantel was more than 1mg/L, the contractures of schistosomiasis were immediately intense. The muscular contraction of the parasite may be related to the loss of intracellular calcium ions due to the increase of membrane permeability of the somatic cells by praziquantel.

 

2. Insect cortex damage and host immune function: Prazizitel has a rapid and obvious damage to the insect cortex, causing swelling of the outer skin of the syncytium, vacuoles, bullae, protrusion of the body surface, and finally the epidermis erosion and ulceration, almost all secretory bodies disappear, and the annulus muscle and the longitudinal muscle also rapidly dissolve successively. In the host, external skin vacuolar degeneration was observed 15 minutes after administration. After the destruction of the cortex, the absorption and excretion functions of the parasite are affected. More importantly, the exposure of the body surface antigen makes the parasite vulnerable to the immune attack of the host. A large number of eosinophils attach to the skin lesions and invade, leading to the death of the parasite. In addition, praziquantel can also cause secondary changes, depolarizing the surface membrane of the insect body, significantly reducing the alkaline phosphatase activity of the cortex, resulting in inhibition of glucose uptake and depletion of endogenous glycogen. Praziquantel can also inhibit the synthesis of nucleic acids and proteins.

 

Pharmacokinetics

After oral absorption is rapid, more than 80% of the drug can be absorbed from the intestine. The peak value of blood drug reached about 1 hour, and the drug was metabolized quickly after entering the liver, mainly forming hydroxyl metabolites, and only a very small amount of unmetabolized active drug entered the systemic circulation. The concentration in portal venous blood can be 10 times higher than that in peripheral venous blood. The concentration of cerebrospinal fluid is about 15%-20% of the concentration of blood drugs. After lactation patients take medicine, the concentration of drugs in their milk is equivalent to 25% in serum. The peak blood dose after oral administration of 10-15mg/kg is about 1mg/L. Drugs are mainly distributed in liver, followed by kidney, lung, pancreas, adrenal gland, pituitary gland, salivary gland, etc., rarely through the placenta, no organ-specific accumulation phenomenon. Its half-life (T1/2) is 0.8-1.5 hours, and its metabolites have a half-life (T1/2) of 4-5 hours. It is excreted mainly by the kidneys in the form of metabolites, 72% within 24 hours and 80% within 4 days.

 

FAQ

Q1: Are you a manufacturer?


Answer: Yes, we are factory founded on 2010.

Q2: How to contact with us?


Click the "Contact Supplier" And then send us message the product you interest in, you will get valid reply within TWO hours.

Q3:Which kind of payment terms do you accept?


For small order,you can pay by T/T,Western Union or Paypal,nomal order by T/T to our company account

Q4:Can you give me a discount price?


Sure,It depends on your qty.

Q5:How can i get a sample?


free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your
order in the future.

Q6: How to confirm the Product Quality before placing orders?


A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the
samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q7:How do you treat quality complaint?


A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us,
we will send you free goods for replacement or refund your loss.

 

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