|
Items of Test
|
Standard
|
Result of Test
|
|
Descriptions
|
White or partically white crystalline powder
|
conforms
|
|
Melting point
|
136-142°C
|
137-138°C
|
|
Identification
|
Consistent with the IR spectrum for reference standard
|
Conforms
|
|
Loss on drying
|
≤0.5%
|
0.1%
|
|
Residue on ignition
|
≤0.1%
|
0.02%
|
|
Phosphate
|
≤0.05%
|
<0.05%
|
|
Heavy metal
|
≤0.002%
|
<0.002%
|
|
Related substances
|
A≤0.2%
B≤0.2%
C≤0.2%
|
0.06%
0.06%
ND
|
|
Residual solvent
|
Ethanol ≤5000ppm
Chloroform ≤60ppm
|
45ppm
ND
|
|
Assay
|
98.5%-101.0%(dried substance)
|
100.5%
|
Biltricide Description
Biltricide ® (praziquantel) is a trematodicide provided in tablet form for the oral treatment of schistosome infections and infections due to liver fluke.
Biltricide (praziquantel) is 2-(cyclohexylcarbonyl)-1,2,3,6,7, 11b-hexahydro-4H-pyrazino [2, 1-a] isoquinolin-4-one with the molecular formula; C 19H 24N 2O 2. The structural formula is as follows:
Praziquantel is a white to nearly white crystalline powder of bitter taste. The compound is stable under normal conditions and melts at 136-140°C with decomposition. The active substance is hygroscopic. Praziquantel is easily soluble in chloroform and dimethylsulfoxide, soluble in ethanol and very slightly soluble in water.
Biltricide tablets contain 600 mg of praziquantel. Inactive ingredients: corn starch, magnesium stearate, microcrystalline cellulose, povidone, sodium lauryl sulfate, polyethylene glycol, titanium dioxide and hypromellose.
Application
★ Praziquantel is an anthelmintic or anti-worm medication. It prevents newly hatched insect larvae (worms) from growing or multiplying in your body.
★ Praziquantel is used to treat infections caused by Schistosoma worms, which enter the body through skin that has come into contact with contaminated water.
★ Praziquantel is also used to treat infection with liver flukes, caused by a type of worm found in East Asia. This worm enters the body while eating contaminated fish.
Your message must be between 20-3,000 characters!