Function&Application
1. This product acts on the infrared phase of plasmodium vivax, and acts on the red phase of chloroquine combined, can cure plasmodium vivax.
2. Mipaline (atapine) and chloroguanidine can inhibit the metabolism of primaquine, so the plasma concentration of primaquine is greatly increased, the maintenance time is prolonged, and the toxicity is increased, but the curative effect is not increased.
3. It is not suitable for use with other drugs that have hemolysis and inhibit the hematopoietic function of bone marrow.
This product can kill plasmodium vivax, plasmodium malariae, plasmodium falciparum and plasmodium ovale tissue strains, especially plasmodium vivax. It can also kill gametophytes of various plasmodium parasites, especially plasmodium falciparum, so that it can not develop in the mosquito body, so as to block transmission. The effect of this product on red endozoa is very weak. The antimalarial mechanism of primaquine is not completely clear, which may be related to the interference of DNA synthesis. After the plasmodium and tissue cells were cultured together in primaquine solution for 8 hours, it was observed by electron microscopy that primaquine could change the morphology of plasmodium mitochondria, which was manifested as mitochondrial swelling and cytoplasmic vacuoles. The drug inhibited mitochondrial oxidation and significantly reduced the oxygen uptake of the malaria parasite. Primaquine is metabolized in vivo and transformed into quinoline quinone derivatives with strong oxidation properties, which can transform the reduced glutathione (GSH) in erythrocytes into oxidized glutathione (GSSH). When the latter is reduced, the reduced coenzyme ⅱ (NADPH) is consumed. Coenzyme ⅱ (NADP) has already been consumed during the development of plasmodium in the liver parenchymal cells during the infrared phase. However, primaquine interferes with the reduction of coenzyme ⅱ and reduces the reduction of coenzyme ⅱ, which seriously damages the glucose metabolism and oxidation process of plasmodium.
FAQ
Q1: Can i get some samples?
A: Yes, we can supply the free sample, but the shipping cost need to be paid by our customers.
Q2:Which kind of payment terms do you accept?
A: Payment by T/T, Western Union or Bitcoin.
Q3.Which transportation do we use?
A:Samples could be DHL, UPS, TNT, EMS, Fedex, and so on. For mass orders, it will be delivered by air or sea.
Q4:How about your delivery time?
Generally, it will take 3 to 5 days after receiving your advance payment.
Q5:How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q6. How can we trust you?
A: You are always warm welcomed to visit us at any time.Before we start B2B, MIC has audited our company on-spot and approved our credit.
Q7.Do you test all your goods before delivery?
A:Yes, we have 100% test before delivery,International Authorized Third-Party Test for the products if you need are highly welcomed.
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