Product Description
Doxazosin Mesylate 99% Hypotensive API Fine Powder Cas 77883-43-3 Doxazosin Mesylate Powder with top quality from China !
Specification of Analysis
| Items |
Standard |
Results |
| Appearance |
White or off white crystalline powder.odourless tasteless.
lightly soluble in water,methanol soulution,soluble in mixed solution of 15 volume water and 35 volume tetrahydrofuran,almost unsoluble in actone |
Conform |
| Identification(1) |
The retention time of the main peak of the supplier should be consistent with the retention time of the control peak of doxazsin mesylate. |
Conform |
| Identification(2) |
The infrared absorption spectra of this product should be consistent with the control map(spectral set 733) |
Conform |
| PH |
2.5~4.5 |
3.9 |
| Cl- |
≤0.06% |
Conform |
| Related substance |
Each impurity not more than 0.10%
Sum of impurities not more than 0.3%
Methanol≤0.3%
Ethyl acetate≤0.5% |
0.034%
0.07%
N.D
N.D |
| Organic solvent residue |
N-butanol≤0.5%
Toluene≤0.089%
Dichloromethane≤0.06% |
N.D
N.D
N.D |
| Heavy metals |
Not more than 10ppm |
Conform |
| Loss on drying |
Not more than 1.0% |
0.47% |
| Methyl methanesulfonate |
Not more than 1900ppm(0.19%) |
N.D |
| Residue on ignition |
≤0.1% |
0.04% |
| Assay |
Not less than 98.0%~102.0%(dried substance) |
99.7% |
| Microbial limit |
Should be meet the requirements |
Meet the requirements
|
What is Doxazosin mesylate ?
Doxazosin mesylate is mainly used in patients with primary mild to moderate hypertension and hypertension with benign prostatic hypertrophy. Doxazide can be used in combination with thiazide diuretics and β -blockers, calcium antagonists, or angiotensin converting enzyme inhibitors for patients whose blood pressure is difficult to control with a single drug.
Mesylate sandy azole lamictal is developed by China listed on the new generation of quetiapine alpha 1 receptor blockers azole ketones, the long half-life, reached by blocking a1 receptors to dilate blood vessels, reducing vascular resistance, lower blood pressure, selective blocking smooth muscle matrix, capsule of prostate and bladder neck a1 adrenaline receptors, improve the symptoms of benign prostatic hyperplasia patients, At the same time, it has a good effect on dysuria caused by simple prostatic hyperplasia. In 1988, doxazosin was marketed in Denmark as a drug for the treatment of hypertension. In 1995, doxazosin was approved by FDA for the treatment of benign prostatic hyperplasia. In September 2002, doxazosin controlled release tablets were marketed in China, providing a new choice for the drug treatment of benign prostatic hyperplasia in the national Chemicalbook. At present, it has been clinically recommended as a first-line drug for anti-hypertension and prostate diseases abroad. [Pharmacological Action] This product is a new type of highly selective α1 receptor blocker, which can significantly reduce blood pressure, improve lipid metabolism, and significantly reduce serum triglyceride and total cholesterol. In addition, selective blocking of the prostate smooth muscle matrix, capsule and bladder neck of a1 adrenalin receptor, improve the symptoms of benign prostatic hyperplasia patients, significantly reduce the effect of benign prostatic hyperplasia, especially for simple prostatic hyperplasia caused by dysuria has a good effect, its half-life is long.
Usage and dosage:
Commonly adult oral dose, apply an initial dose of 1mg, once a day. After 1-2 weeks, adjust the dosage according to the clinical response and tolerance; for first dose and dose adjustment, it is preferably taken at bedtime. Maintenance dose of 1-8mg, once a day, but over 4 mg can cause orthostatic hypotension. Foreign research data suggest that the maximum dose of this product to 16mg/day.
Pediatric dose has not been determined.
FAQ
Q1: Are you a manufacturer?
Yes, Wango Biopharm have concentrated on Organic synthesis over 12 years since 2008.
Advanced R&D technology, 380,000 categories chemical reagent are in stock.
Trading products we will serve for you with our ISO supplier system, making your purchasing risk into the lowest.
In addition, we provide the customization service of a new compound from lab to bulk manufacturing.
Q2: How to contact with us?
You can contact with us on Made-in-China, the Average Response Time is 0-4h on Work time, <24h on Non-work time.
For every inquiry, our sales will provide the one-for-one service for you.
Q3:Which kind of payment do you accept?
Normal orders: Company account(The price will be 5%-13% extra discount)
Sample/small orders: Paypal(The 5-10% extra fee),Western Union etc.
About the payment term, we will negotiate alone.
Q4:How to confirm the Product Quality before placing orders?
1st, you can get free samples for some products, just pay the basic cost for us.
2nd,Also you can send the specification or your quest to us, we will customize the products for you.
3rd,We emphasis that our whole company make a living with organic chemical and customers, we absolutely impossible to sale any fake goods, unqualified goods, it is shame! And None False certificate/lie/illegal thing in our sales net!
Q5:How do you treat quality complaint?
The customer complaint handling procedures is the key part in Our ISO management system. We will set up an investigation team for your complaint, and give the handling plan and our corrective and preventive measures within a limited time.
Q6:Package
We will refer the MSDS to design the package standard and show you at the PI or Quotation list.
If you want customize package and haven't go against the principle of science, we will do as your request. The cost will be calculate your request.
For dangerous goods, only one style of package, we will do as the UN standard.
Q7:Shipping
We have R&D and manufactured chemicals for 12 years, we have rich experience on Shipping, Many famous companies cooperated with us stably, we are good at shipping all kinds of chemicals.
General goods: The best service, price and lead time.
Dangerous goods: The professional cooperated company, the details please check our website.
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