Rhinitis Treatments by Levocetirizine HCL 99% fine powder

Function of Levocetirizine hydrochloride

[In vivo process] Levo-cetirizine is the levo-body of cetirizine, which has a high binding rate with plasma protein after oral absorption into the blood. The effect of levo-cetirizine is more obvious one hour after oral absorption, and the duration is 24.4 hours, respectively, and the effect reaches its peak within 6 hours after taking the drug. Pharmacokinetic studies confirm that consists of two equal amounts antipodal structure of cetirizine racemic in the body's metabolism without liver, oral cetirizine sinistral 4 hours and 8 hours after plasma concentrations of cetirizine is almost right twice, it's main metabolites in urine, oral 32 hours after 50% - 60% of the drugs by urine excretion, a small amount of waste discharge.

Cetirizine 】 【 pharmacological mechanism sinistral developed by Belgium UCB company, with the SuoFei that, desloratadine, b fluorine lamictal is listed as the third generation of anti-allergic drugs, such as because of cetirizine is left-handed, so pharmacological effects similar to those of cetirizine, but fewer side effects, cetirizine had mild inhibitory effect on central nervous system, Research shows that cetirizine inhibition of the central nervous system is mainly the right body has certain affinity with related receptors in the brain, so a single optical isomer of cetirizine cetirizine - left-handed cetirizine avoided ably to central nervous system side effects such as sedation, sleepiness, antihistamine activity is similar to cetirizine. Levocetirizine has a stronger anti-allergic effect than other anti-allergic drugs because of its extensive pharmacological mechanism. In addition to its strong antagonistic effect against H1 receptor, it also has other anti-allergic mechanisms. The pharmacological mechanisms associated with asthma include inhibition of the aggregation and infiltration of inflammatory cells mainly composed of eosinophils in the airway, inhibition of the degranulation of hypertrophic/basophils, inhibition of delayed asthmatic response, and enhancement of the bronchodilation of β 2-adrenergic receptor agonists.

In order to study the curative effect of cetirizine enantiomorphism structure, in healthy adult volunteers used cetirizine, cetirizine left-handed and right-handed cetirizine (Ucb28557) on skin allergic reaction caused by histamine, randomized, double-blind and cross experiment results show that cetirizine and cetirizine sinistral of histamine induced skin rash and flush has significant inhibitory effect, The antihistamine activity of 2.5mg levo-cetirizine was superior to that of 5mg cetirizine, suggesting that the efficacy of levo-cetirizine was superior to that of cetirizine, while dexcetirizine showed no antagonistic effect against H1 receptors.

[Clinical Application] As a third-generation antihistamine, Levistirizine was marketed in February 2001. It is a single optical isomer of the second-generation antihistamine cetirizine, which is mainly used for the treatment of allergic diseases in respiratory system, skin and eyes, such as allergic rhinoconjunctivitis, allergic skin disease, allergic asthma, etc. It has the advantages of fast effect, strong and lasting effect and few side effects.

[Usage and dose] The usual clinical dose for adults is 5mg, once a day.

[Side effects] No central nervous system side effects such as sedation and drowsiness; No arrhythmia-inducing effect of second generation antihistamines (e.g. Terfenadine, asimidazole, etc.) was observed.

[Notes] It is applicable to a wide range of people, and can be used for pregnant and lactating women. It is classified as class B (relatively safe) for pregnant women by FDA of the United States. It is also safe for children (including infants) in clinical use.

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