Enrofloxacin and salfloxacin, dafloxacin, difloxacin, ofloxacin, norfloxacin and obifloxacin are the third generation of fluoroquinolone

broad-spectrum antibacterial drugs commonly used in veterinary clinic. Enrofloxacin is the ethyl compound of oxacin. Also known as

ethyl crofloxacin, ethyl cprofloxacin and enfloxacin, it is effective against gram-negative bacteria, gram-positive bacteria and

mycoplasma, and its antibacterial activity is obviously better than norfloxacin, and its effect on mycoplasma is stronger than

tylosinin and tiemomycin. This product is easily absorbed by oral administration, muscle and subcutaneous injection, and

widely distributed in the body. Except for the central nervous system, the drug concentration in other tissues is almost higher

than that in blood. In vivo, the ethyl can be deethyl, mainly to produce the active metabolite cprofloxacin, but in animals, the

metabolic rate is high in poultry, dogs, rabbits and cattle, the metabolic rate is low in horses and pigs. Clinical enrofloxacin is

mainly used for the treatment of various mycoplasmosis, escherichia coli, Salmonella, haemophilus, erysipelas, staphylococcus,

streptococcus caused by respiratory system, digestive system, urinary and reproductive system infection, skin infection and

septicemia. It is especially suitable for mixed infection caused by a variety of bacteria. The above information was edited by

Yaoyao of Chemicalbook. Reasonable 1, um, the effect with aminoglycoside (gentamycin), the third generation of cephalosporin

class, cefotaxime, ceftriaxone, etc.) and penicillin kind, slime molds with application of certain bacteria (especially pseudomonas

aeruginosa or enterobacteriaceae bacteria) may show significant antibacterial action, besides penicillin drugs, enhanced due to

the toxicity, when used to reduce the dose, and drug delivery respectively. 2, enrofloxacin and apramycin combined with enhanced

antibacterial activity, showing a synergistic effect. Reason is that the antibacterial mechanism of toxin is can prevent bacterial protein

biosynthesis in specific, and thus to restrain and kill bacteria, but grace of sand can be A specific effect on bacterial DNA cyclotron

enzyme subunit, inhibit its activity, affect DNA chain and chain closure process solution, the combination of double block bacterial

replication and the translation process. 3, mixed with colistin sulfate in the same day, respectively, can improve the efficacy of

enrofloxacin on chicken bacterial disease. Topical therapy with SD silver for Chemicalbook inflammation of the ear in dogs.

References: Hu Gongzheng, Cui Yaoming. Rational compatibility of veterinary drugs. Zhengzhou: Henan Science and Technology

Press.2009. Incompatibility 1, enrofloxacin can inhibit the metabolism of theophylline and caffein, so that its blood drug concentration

increases, resulting in toxic reaction. 2, the bioavailability of enrofloxacin decreased when combined with anticholinergic agents

(atropine, 654-2) and H2 receptor antagonists (cimetidine, famotidine). 3, enrofloxacin has the effect of inhibiting liver drug enzyme,

and the drug metabolism in the liver, such as erythromycin, lincomycin, etc., can make its clearance rate reduced, blood drug concentration

increased. 4, acid-making drugs can reduce the absorption of enrofloxacin in the gastrointestinal tract, and should not be used together. 5,

mixed with strong acidic liquid or strong alkaline liquid precipitation. 6, enrofloxacin and metoclopramide chemical changes, easy to become

cloudy, should not be mixed injection. Enrofloxacin has low toxicity and is safe for clinical use. There was no teratogenic and mutagenic effect

at the treatment dose. Can make young animal cartilage turbid change, cause claudication and pain. Digestive reactions include vomiting,

abdominal pain, and bloating. Skin reaction has erythema, pruritus, urticaria and photosensitive reaction. Note ① Enrofloxacin aqueous solution

is easy to discoloration and decomposition when exposed to light, so it should be stored away from light. ② The drug resistance strains are

increasing, so it should not be used for a long time at a subtherapeutic dose. ③ Acid-making agent can inhibit the absorption of the product,

so avoid drinking it at the same time. ④ In clinical application, the dose can be adjusted appropriately according to the disease, and the

concentration range of drinking water for poultry is 25 ~ 100 mg per liter of drinking water. ⑤ The withdrawal period of chickens is 8 days.

Forbidden during laying period of laying hens. ⑥ Chickens are very sensitive to enrofloxacin injection. There have been many reports of

poisoning in China, so the dose should be strictly controlled. Chemical properties The product is the third generation of quinolone antibacterial

drugs, for special veterinary drugs, is a kind of white or light yellow crystalline needle powder, melting point 221-226℃, odorless, tasteless.

Commonly used its hydrochloride, lactate salt, sodium salt. The product is dissolved in acid or alkaline conditions, slightly dissolved in dimethyl

formamide, chloroform, slightly dissolved in methanol, insoluble in water. The color of this product is deepened by prolonged illumination. Store

in the place with high relative humidity, easy to absorb moisture and agglomerate. Use for antibacterial, suitable for bacteria and mycoplasma i

nfection. Use As veterinary antibacterial drugs use new veterinary antibacterial drugs, broad spectrum, high efficiency, gram-positive bacteria

and mycoplasma has special effects .