China Pharma Pure Powder manufacturer

GS441524 API Active Pharmaceutical Ingredient For FIP Treatments

Product Details:
Place of Origin: Xi'an ,China
Brand Name: Wango
Model Number: GS441524
Payment & Shipping Terms:
Minimum Order Quantity: 100 gram can be shipped by TNT ,Fedex ,or DHL .
Price: FOB price 10000usd /kg
Packaging Details: 1kg Aluminium Foil Bag/ 25 Paperdrum
Delivery Time: 3-7 days

Detail Information

Packing: 1mg,1g,10g Small Bottle Cas: GS441524
Function: FIP Treatments Purity: 99%min
Type: Amino Acids And Coenzymes Grade Standard: Medicine Grade
Mf: C32H32Cl2O8 Usage: Animal Pharmaceuticals
High Light:

CAS GS441524 Active Pharma Ingredient

,

FIP Treatments API Powder

Product Description

GS441524 99% Purity For FIPV Treatments Of Your Cats Cas 1191237-69-0

 

Name

Structure

 

 

 

 

 

NH2

(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-

3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbon

 

HO

 

 

 

N

N

itrile

 

O

 

N

 

 

 

 

 

N

 

 

HO

 

OH

 

 

CAS No.

1191237-69-0

Batch number

WG055210905L

Report date

2021.09.17

Producing date

2021.09.15

Retest date

2023.09.14

 

 

 

 

 

 

 

 

 

 

Items

Specifications

Results

Appearance

A white to off-white or yellow solid

off-white powder

 

 

 

 

Identification

The infrared spectrum of the sample is consistent with that of the reference standard, similarly,

measured.

Complies

The 1H NMR spectrum of the sample in deuterated dimethyl sulfoxide (DMSO-d6) is consistent with

that of a similarly measured reference spectrum

Complies

The retention time of the main peak of the sample

is consistent with that of the reference standard.

Complies

 

Related Substance

Any unspecific individual impurity NMT 0.40%

0.09%

Total impurity NMT 3.0%

0.37%

Assay(HPLC)

NLT 97.0%

99.61%

Conclusion

The product conforms to the above specifications

Storage

Sealed preservation at room temperature

GS441524 API Active Pharmaceutical Ingredient For FIP Treatments 0GS441524 API Active Pharmaceutical Ingredient For FIP Treatments 1GS441524 API Active Pharmaceutical Ingredient For FIP Treatments 2GS441524 API Active Pharmaceutical Ingredient For FIP Treatments 3Additional test

ELEMENTAL IMPURITY CONTENT BY ICP-MS

Boron

 

Neodymium

 

 

What is  GS441524 ?

 

Gs-441524 is the second targeted antiviral agent after GC376 for feline infectious peritonitis (FIP). Gs-441524 is a small molecule nucleotide analogue provided by GileadSciences(NO.1 in the world antiviral field) to PerdersenNCjiaoshou2 and its abdominal transabdominal research topic at UCDavis (NO.1 in the world Chemicalbook veterinary medicine). It is a reverse transcriptase inhibitor that can inhibit the replication of feline ventral virus (FIP) and is a prerequisite molecule for the synthesis of nucleoside triphosphate with pharmacological activity .

 

Gs-441524 is a small molecule, known as a competitive nucleoside triphosphate inhibitor, showing strong antiviral activity against many RNA viruses. Can inhibit the replication of several different types of RNA viruses, such as zoonotic severe Chemicalbook acute respiratory syndrome (SARS) coronavirus, Middle East respiratory syndrome virus, Ebola virus, Lassa fever virus, Junin virus and respiratory syncytial virus, while showing low cytotoxicity in a wide range of cell lines .

 

Feline infectious peritonitis (FIP) is a devastating and almost always fatal feline disease resulting from a mutation of the common feline coronavirus (FECV), which infects 40-80% of cats worldwide. Gs-441524, also known as GS-5734, is an effective inhibitor of feline infectious peritonitis (FIP) virus. Gs-441524 showed strong inhibition against feline infectious peritonitis (FIP) virus Chemicalbook. Gs-441524 is a molecular precursor of a pharmacologically active nucleoside triphosphate molecule. These analogues can be used as surrogate substrates and RNA chain terminators for viral RNA-dependent RNA polymerases. Gs-441524 was non-toxic in feline cells with concentrations up to 100, and effectively inhibited FIPV replication in CRFK cell culture and natural infection in cat peritoneal macrophages with concentrations as low as 1

 

GS441524 API Active Pharmaceutical Ingredient For FIP Treatments 4

 

 

 

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