Product Details:
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Place of Origin: | xi'an ,China |
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Brand Name: | Wango |
Certification: | GMP |
Model Number: | W-278 |
Payment & Shipping Terms:
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Minimum Order Quantity: | 1kilogram |
Price: | FOB price 88-97usd/kg base on 25kg MOQ |
Packaging Details: | 1kg/bag, 25kg/drum according to your requirements |
Payment Terms: | Western Union, L/C, T/T, Western Union, MoneyGram |
Supply Ability: | 2000kilogram every month |
Detail Information |
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Name: | Nifedipine | Cas: | 21829-25-4 |
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Function 1: | Antihypertensive | Function 2: | Antianginal |
Highlight: | Pharmaceutical Nifedipine USP,Antihypertensive Nifedipine USP |
Product Description
COA
TEST |
SPECIFICATIONS |
RESULT |
DESCRIPTION |
Yellow crystalline powder , odourless , and unstable when met light |
Yellow crystalline powder , |
IDENTIFICATION |
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A. IR SPECTRUM |
INFRARED ABSORPTION < 197K > : |
Concordent with the reference |
B. TLC |
The retention time of the major peak of the Sample solution corresponds to that of the Standard solution, as obtained in the Assay. |
Complies |
ORGANIC IMPUIRTIES( By HPLC ) |
Nifedipine nitrophenylpyridine analog a : NMT 0.2 % ; |
Impurity a : 0.01 % |
LIMIT OF CHLORIDE AND SULFATE |
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Chloride |
NMT 0.02 % |
Less than 0.02 % |
Sulfate |
NMT 0.05 % |
Less than 0.05 % |
PERCHLORICE ACID TITRATION |
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Perchloric acid |
NMT 0.12 mL |
Less than 0.12 mL |
SPECIFIC TESTS |
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Loss on d ing < 731> |
≤ 0.5 % |
0.1 % |
Residue on ignition < 281 > |
≤ 0.1 % |
0.05 % |
Heavy metals |
Not more than 10 PPM |
Less than 10 PPM |
Microbial Limits |
Total aerobic bacteria count : ≤ 1000 cfu / g |
Total aerobic bacteria count :15 cfu/g |
ASSAY |
Nifedipine contains NLT 98.0 % and NMT 102.0 % of |
99.6 % |
Function :
Nifedipine is a dihydropyridine calcium antagonist, can inhibit myocardial and vascular smooth muscle on the Ca 2+ uptake, expandthe coronary artery, increase coronary blood flow, improve the heart muscle Ischemia tolerance, while it can expand the surrounding arterioles, reduce peripheral vascular resistance, relieve coronary spasm, increase coronary flow, improve myocardial hypoxia, and thus reduce blood pressure. Low-dose coronary dilation does not affect blood pressure, and is a good anti-angina drug. For the prevention and treatment of coronary heart disease angina, no adverse effects on respiratory function, especially for angina caused by coronary artery spasm and angina pectoris with the best effect of respiratory obstructive disease, itsefficacy is better than β-blockers. It is also suitable for various types of hypertension, including severe and refractory .
Hypertension.
Treatment of intractable congestive heart failure can be long-term use of this product. Also used to treat primary pulmonary hypertension, diffuse esophageal spasm and bronchial asthma, duodenal ulcer, urinary tract obstruction , exercise asthma,achalasia and so on.
Nifedipine has certain selectivity for vascular smooth muscle, and its direct negative inotropic and degenerative effects on the heart are weak. Therefore, systemic administration does not cause heart rate to slow down and manifests as increased heart rate reflex.
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