China Pharma Pure Powder manufacturer

Antihypertensive Antianginal Pharmaceutical Nifedipine USP 99%

Product Details:
Place of Origin: xi'an ,China
Brand Name: Wango
Certification: GMP
Model Number: W-278
Payment & Shipping Terms:
Minimum Order Quantity: 1kilogram
Price: FOB price 88-97usd/kg base on 25kg MOQ
Packaging Details: 1kg/bag, 25kg/drum according to your requirements
Payment Terms: Western Union, L/C, T/T, Western Union, MoneyGram
Supply Ability: 2000kilogram every month

Detail Information

Name: Nifedipine Cas: 21829-25-4
Function 1: Antihypertensive Function 2: Antianginal
High Light:

Pharmaceutical Nifedipine USP

,

Antihypertensive Nifedipine USP

Product Description

Nifedipine USP 99% antihypertensive and antianginal pharmaceutical powder  

COA 

 

TEST

SPECIFICATIONS

RESULT

DESCRIPTION

Yellow crystalline powder , odourless , and unstable when met light

Yellow crystalline powder ,
odourless , and unstable when
met light

IDENTIFICATION

A. IR SPECTRUM

INFRARED ABSORPTION < 197K > :
The IR absorption spectrum should be concordent with the spectrum obtained with Nifedipine working reference standard.

Concordent with the reference
spectrogram

B. TLC

The retention time of the major peak of the Sample solution corresponds to that of the Standard solution, as obtained in the Assay.

Complies

ORGANIC IMPUIRTIES( By HPLC )

Nifedipine nitrophenylpyridine analog a : NMT 0.2 % ;
Nifedipine nitrosophenylpyridine analog b : NMT0.2 %

Impurity a : 0.01 %
Impurity b : ND

LIMIT OF CHLORIDE AND SULFATE

Chloride

NMT 0.02 %

Less than 0.02 %

Sulfate

NMT 0.05 %

Less than 0.05 %

PERCHLORICE ACID TITRATION

Perchloric acid

NMT 0.12 mL

Less than 0.12 mL

SPECIFIC TESTS

Loss on d ing < 731>

≤ 0.5 %

0.1 %

Residue on ignition < 281 >

≤ 0.1 %

0.05 %

Heavy metals

Not more than 10 PPM

Less than 10 PPM

Microbial Limits

Total aerobic bacteria count : ≤ 1000 cfu / g
Total combined moulds / yeasts count : ≤ 100 cfu/g
Escherichia coli : Absence

Total aerobic bacteria count :15 cfu/g
Total combined moulds / yeasts count : < 10cfu/g
Escherichia coli : ND

ASSAY

Nifedipine contains NLT 98.0 % and NMT 102.0 % of
nifedipine ( C17H18N2O6 ), calculated on the dried basis

99.6 %

 

Function  :

 

Nifedipine is a dihydropyridine calcium antagonist, can inhibit myocardial and vascular smooth muscle on the Ca 2+ uptake, expandthe coronary artery, increase coronary blood flow, improve the heart muscle Ischemia tolerance, while it can expand the surrounding arterioles, reduce peripheral vascular resistance, relieve coronary spasm, increase coronary flow, improve myocardial hypoxia, and thus reduce blood pressure. Low-dose coronary dilation does not affect blood pressure, and is a good anti-angina drug. For the prevention and treatment of coronary heart disease angina, no adverse effects on respiratory function, especially for angina caused by coronary artery spasm and angina pectoris with the best effect of respiratory obstructive disease, itsefficacy is better than β-blockers. It is also suitable for various types of hypertension, including severe and refractory .

 

 

Hypertension.

Treatment of intractable congestive heart failure can be long-term use of this product. Also used to treat primary pulmonary hypertension, diffuse esophageal spasm and bronchial asthma, duodenal ulcer, urinary tract obstruction , exercise asthma,achalasia and so on.
Nifedipine has certain selectivity for vascular smooth muscle, and its direct negative inotropic and degenerative effects on the heart are weak. Therefore, systemic administration does not cause heart rate to slow down and manifests as increased heart rate reflex.

 

Antihypertensive Antianginal Pharmaceutical Nifedipine USP 99% 0

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