99% Research Chemical Ramosetron HCL Cas 132907-72-3

Product Description

Ramosetron HCL 99% Research Chemical Cas 132907-72-3  

Product Name	Ramosetron hydrochloride
CAS NO.	132907-72-3
Appearance	White powder
Purity	99%
Melting point	244-246°C
Solubility	H2O: soluble20mg/mL, clear
Application	Organic raw materials; pharmaceutical raw materials; intermediates; API
Chemical structure
Usage	Prevent and treat gastrointestinal symptoms such as nausea and vomiting caused by anti-malignant tumor drug treatment.
Storage	Normal Temperature

It is indicated for the prevention and treatment of gastrointestinal symptoms such as nausea and vomiting caused by anti-malignant drug therapy. Pharmacological Action 5-HT3 receptor/antagonistic effect This drug showed antagonistic effect on 5-HT3 receptor in guinea pig colon contraction test and rat and ferret slow heart rate reflex (Bezold-Jarisch reflex) test induced by 5-ht3. Anticancer drug-induced vomiting inhibition showed inhibition of cisplatin induced vomiting in ferrets before the onset of vomiting or after the initial vomiting. Mechanism of action Anti-malignant agents such as cisplatin can dissociate 5-chemicalbook serotonin from chromaffin cells in the digestive tract. 5-hydroxytryptamine binds to 5-HT3 receptor, which is transmitted to the end of the vagus nerve in the digestive tract, and stimulates the vomiting center to induce vomiting. Ramosetron hydrochloride works by blocking the 5-HT3 receptor. Bioactivity Ramosetron hydrochloride (YM-060) is the hydrochloride form of Ramosetron, and ramosetron is a selective serotonin(5-HT)receptor antagonist with potential antiemetic effects.