Cas 204656-20-2 Semaglutide Weight Loss 98% Novel Antidiabetics Purity

Description  :

On December 5, 2017, the U.S. Food and Drug Administration (FDA) approved Semaglutide, the first oral glP-1 analogue.

The MARKET for GLP-1-like diabetes drugs was $3 billion in 2014 and is expected to reach $9 billion in 2019. At present, all the glucose-lowering drugs similar to GLP-1 on the market are administered by subcutaneous injection, and there is no oral drug on the market. Semaglutide, an oral GLP-1 analogue, was released on Novo Nordisk's official website on February 20, 2015. The results of a phase II clinical trial of Semaglutide (OG217SC) showed that Semaglutide met the expected clinical outcome in the treatment of type 2 diabetes. This makes the majority of diabetes patients see the victory of oral GLP-1 analogue drugs.

In 2005, the FDA approved Astrazeneca's first GLP-1 analogue, Exenatide, for the treatment of type 2 diabetes by subcutaneous injection. Since Exenatide came on the market, glP-1 analogues, which were administered once a day and once a week, have been continuously on the market, enriching the variety of GLP-1 analogues. At present, all the listed GLP-1-like diabetes drugs are administered by subcutaneous injection, and it is difficult to develop oral dosage forms. Novo Nordisk appears to have cracked the technical hurdles of oral delivery of these peptide treatments, and is counting on the success of Semaglutide to dominate the diabetes market more strongly. Because oral dosage forms are difficult to develop, novo Nordisk is also developing a subcutaneous version of Semaglutide, which is in phase III clinical trials, as an insurance policy. If Semaglutide goes ahead, it will add to the growing competition in the glucose-lowering market for GLP-1 analogues.

The Phase II trial of Semaglutide (OG217SC) in oral dosage form enrolled 600 patients with type 2 diabetes. Patients were divided into three groups: Semaglutide orally, Semaglutide subcutaneously, and placebo. HbA1c levels were 0.7-1.9% lower in the Semaglutide group; Hemoglobin a1c levels dropped 1.9 percent in the Semaglutide group and 0.3 percent in the placebo group. Weight loss at the maximum dose of oral Semaglutide was comparable to that of the injected group.

Novo Nordisk is considering a Phase III clinical trial of Semaglutide, an oral dosage form. But a big problem with the oral version of Semaglutide is the dose. Clinical data show that Semaglutide oral formulation requires 300 times more active ingredient dose than subcutaneous injection, i.e., Semaglutide is administered once a week with 1 mg each time to achieve good hypoglycemic effect. If given orally, take 40 milligrams of Semaglutide daily. Therefore, even if the oral dosage form can be successfully launched, it will inevitably cost a lot of money. Therefore, people are concerned about the commercial potential and market prospects of Semaglutide oral dosage form.

Why Choose Us Wango biopharm?

1. High-concentration products, strictly control the quality.
2. Reasonable and flexible price matched with high quality.
3. Spot samples can be shipped quickly after payment, saving time for receiving goods.
4. Full experience of large numbers containers loading in Chinese sea port.
5. Safe raw materials from China.
6. Have professional customs clearance capabilities and the best after-sales service.

7. Manufaturer supply directly, cost less.

Wango biopharm Service

1.Cooperate with research institutions, we strictly control the process from raw material to finished product.
2.The customer comes first, we provide reasonable price, high quality product and prompt shipment.
3.We can send the goods to your delivery address directly. It is relatively safe and fast.
4.Quick and clear response to customers questions.
5.We could make our price discount if you place a substantial order with us.
6.Products can be packaged according to customer requirements.

F.A.Q

1:Can I get some samples before bulk order?
Most products provide free samples, but the shipping cost be paid by customers.

2: What's your MOQ?
For the high value product, our MOQ starts from 10g,100g and 1kg.

3: Which kind of payment terms do you accept?
PI will be sent first after confirmation of order,enclosed our bank information.Payment by T/T, Western Union, L/C, Alibaba trade assurance, Cashapp,Moneygram or Bitcoin.

4.How to place an order?
You can contact me through Email, Wechat, Telphone, Trademanager, WhatsApp, Skype Online and other contact methods, tell me the product and quantity you need, and then we will give you a quote. If you choose one of the above payment methods, we will arrange the delivery for you.

5:How about your delivery time?
A: Generally, it will take 3 to 5 days after receiving your advance payment.

6:How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.