hyperuricemia treatment Allopurinol And Gout crystal powder

 Antigout Allopurinol 99% Cas 315-30-0 China bigggest manufacturer supply 1000kilogram fresh stock !

Properties

This product of purine alcohol and its metabolic product oxygen by inhibiting the activity of xanthine oxidase (the latter could turn hypoxanthine into xanthine, again make xanthine into uric acid), reduce uric acid generated, uric acid levels in the blood and urine reduces to a level below the solubility, thereby preventing uric acid calculi deposition, help tophus and uric acid crystals dissolve again.

Oral digestion is easy to absorb, from the gastrointestinal tract can absorb 80-90%. About 70% of the dose administered is metabolized in the liver to active oxypurinol, neither of which binds proteins. The plasma concentration of allopurinol reaches its peak 2-6 hours after oral administration, and is 2-3μmg/ml at a single dose of 300mg, which can reach 30-50μg/ml in patients with renal impairment. The half-life of β is 1-3 hours and of oxypurinol 12-30 hours (mean 15 hours), with significantly longer duration in patients with renal impairment. This product is excreted by the kidney, about 10% in form and 70% in metabolite are excreted in urine.

This product can be catalyzed by xanthine oxidase in vivo to alloxanthine, alloxanthine and this product can inhibit xanthine oxidase. The affinity of xanthine oxidase to alloxanthine is greater than that to xanthine and hypoxanthine, so that xanthine and hypoxanthine cannot be converted into uric acid by this enzyme, and the uric acid concentration in blood is decreased. The concentration of xanthine and hypoxanthine in the body and excretion in the urine increased, because their solubility is greater than uric acid, so it is not easy to precipitate in the urinary tract, easy to be cleared by the kidney. Since the concentration of uric acid in plasma is reduced to below its solubility level, it not only avoids the deposition of uric acid stones, but also facilitates the redissolution of stones.

This product is anti-gout drugs, suitable for :① chronic primary or secondary gout treatment, but for acute gout attack ineffective, because this product has no anti-inflammatory effect, and may aggravate or prolong the acute stage of inflammation. Colchicine or other anti-inflammatory drugs should be used to control acute gout attacks, especially in the first few months of treatment; ② For the treatment of uric acid nephropathy with or without the symptoms of gout; ③ For patients with recurrent uric acid stones to prevent the formation of stones; ④ It is used to prevent urate deposition and kidney stones in tissues secondary to leukemia, lymphoma or other tumors after chemotherapy or radiotherapy. For uric acid stones that have been formed, it also contributes to stone redissolution.

This product is mainly used for the treatment of gout and the prevention of gout nephropathy, secondary hyperuricemia and severe epilepsy adjuvant treatment.