China Pharma Pure Powder manufacturer

hyperuricemia treatment Allopurinol And Gout crystal powder

Product Details:
Place of Origin: Xi'An,China
Brand Name: wango
Certification: USP 39
Model Number: W-0088
Payment & Shipping Terms:
Minimum Order Quantity: 25kilogram every time
Price: FOB price 60-68usd/kg , can be Negotiable .
Packaging Details: 25kilogram /drum
Delivery Time: 3-5 working days
Payment Terms: L/C, T/T, Western Union
Supply Ability: 1000kilogram every month

Detail Information

Other Name: Zyloprim Function: Hyperuricemia Treatment
State: White Fine Powder Or Crystal Powder Cas: 315-30-0
High Light:

Hyperuricemia Treatment Allopurinol And Gout


Allopurinol And Gout Crystal Powder

Product Description

 Antigout Allopurinol 99% Cas 315-30-0 China bigggest manufacturer supply 1000kilogram fresh stock !


hyperuricemia treatment Allopurinol And Gout crystal powder 0

Chemical Name






Molecular Formula


Molecular Weight







Appearance & Physical State

White to Off-White Solid



Boiling Point

290.8ºC at 760 mmHg

Melting Point


Flash Point


Refractive Index


Water Solubility

0.35 g/L (25 ºC)


Stable under normal temperatures and pressures.

Storage Condition

Store in a tightly closed container. Store in a cool, dry area away from incompatible substances.




This product of purine alcohol and its metabolic product oxygen by inhibiting the activity of xanthine oxidase (the latter could turn hypoxanthine into xanthine, again make xanthine into uric acid), reduce uric acid generated, uric acid levels in the blood and urine reduces to a level below the solubility, thereby preventing uric acid calculi deposition, help tophus and uric acid crystals dissolve again.


Oral digestion is easy to absorb, from the gastrointestinal tract can absorb 80-90%. About 70% of the dose administered is metabolized in the liver to active oxypurinol, neither of which binds proteins. The plasma concentration of allopurinol reaches its peak 2-6 hours after oral administration, and is 2-3μmg/ml at a single dose of 300mg, which can reach 30-50μg/ml in patients with renal impairment. The half-life of β is 1-3 hours and of oxypurinol 12-30 hours (mean 15 hours), with significantly longer duration in patients with renal impairment. This product is excreted by the kidney, about 10% in form and 70% in metabolite are excreted in urine.


This product can be catalyzed by xanthine oxidase in vivo to alloxanthine, alloxanthine and this product can inhibit xanthine oxidase. The affinity of xanthine oxidase to alloxanthine is greater than that to xanthine and hypoxanthine, so that xanthine and hypoxanthine cannot be converted into uric acid by this enzyme, and the uric acid concentration in blood is decreased. The concentration of xanthine and hypoxanthine in the body and excretion in the urine increased, because their solubility is greater than uric acid, so it is not easy to precipitate in the urinary tract, easy to be cleared by the kidney. Since the concentration of uric acid in plasma is reduced to below its solubility level, it not only avoids the deposition of uric acid stones, but also facilitates the redissolution of stones.



This product is anti-gout drugs, suitable for :① chronic primary or secondary gout treatment, but for acute gout attack ineffective, because this product has no anti-inflammatory effect, and may aggravate or prolong the acute stage of inflammation. Colchicine or other anti-inflammatory drugs should be used to control acute gout attacks, especially in the first few months of treatment; ② For the treatment of uric acid nephropathy with or without the symptoms of gout; ③ For patients with recurrent uric acid stones to prevent the formation of stones; ④ It is used to prevent urate deposition and kidney stones in tissues secondary to leukemia, lymphoma or other tumors after chemotherapy or radiotherapy. For uric acid stones that have been formed, it also contributes to stone redissolution.


This product is mainly used for the treatment of gout and the prevention of gout nephropathy, secondary hyperuricemia and severe epilepsy adjuvant treatment.


New clinical use

Fold chronic heart failure

A large number of studies have shown that allopurinol can reduce the incidence of intraoperative and postoperative complications (such as myocardial infarction and arrhythmia) and improve cardiac function in patients undergoing coronary artery bypass grafting and other cardiothoracic surgery. Recent studies have confirmed that allopurinol can indeed improve cardiac function and prognosis in patients with chronic heart failure.


Folded old myocardial infarction (OMI)

Folding progressive muscular dystrophy

Foldable abacterial prostatitis

The level of uric acid in the prostatic fluid is markedly elevated in nonbacterial prostatitis caused by prostatic urine reflux. The use of allopurinol reduces uric acid levels, which in turn improves prostate symptoms. The Persson report confirmed that allopurinol, 300mg daily for 240 days, is safe and effective in chronic abacterial prostatitis and relieves major symptoms of prostatitis within 3 months.


Folding is good for kidney disease

Wang observed the clinical efficacy of prednisone combined with allopurinol in patients with primary nephrotic syndrome.


Folding prevention of 5-FU treatment of bladder tumors caused by drug cystitis

For many years, fluorouracil bladder perfusion treatment of bladder tumors, due to severe chemical cystitis, limited the bladder cytotoxic factors in the application of anti-tumor, Weisner observed 72 elderly patients with multiple diseases, limited by other treatment methods, multiple or repeated postoperative superficial transitional epithelial papillary carcinoma. No obvious symptoms of drug-induced bladder were observed in patients treated with high dose of fluorouracil and oral allopurinol, and the treatment was smooth and effective. This paragraph is from the reference "Pharmacological Effects and New Clinical Uses of allopurinol" by Cheng Bin Ping and Guan Rong Chen.




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