China Pharma Pure Powder manufacturer

Versus Arthritis Gout Medication Allopurinol Fine Powder Cas 315-30-0

Product Details:
Place of Origin: Xi'An,China
Brand Name: wango
Certification: USP 39
Model Number: W-0086
Payment & Shipping Terms:
Minimum Order Quantity: 25kilogram every time
Price: FOB price 60-68usd/kg , can be Negotiable .
Packaging Details: 25kilogram /drum
Delivery Time: 3-5 working days
Payment Terms: L/C, T/T, Western Union
Supply Ability: 1000kilogram every month

Detail Information

Other Name: Zyloprim Function: Versus Arthritis
Cas: Cas 315-30-0 State: White Fine Powder
High Light:

Gout Medication Allopurinol Fine Powder

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Versus Arthritis Gout Medication Allopurinol

Product Description

 Versus Arthritis Of Allopurinol 99% Fine Powder Cas 315-30-0 China bigggest manufacturer supply 1000kilogram fresh stock !

 

Versus Arthritis Gout Medication Allopurinol Fine Powder Cas 315-30-0 0

Chemical Name

allopurinol

Synonyms

AL-100;Pural;1H-Pyrazolo[3,4-d]pyrimidin-4(5H)-one;Apurin;4-HPP;Expand

CAS No.

315-30-0

Molecular Formula

C5H4N4O

Molecular Weight

136.11100

PSA

74.43000

LogP

-0.35380

Properties

Appearance & Physical State

White to Off-White Solid

Density

1.89g/cm3

Boiling Point

290.8ºC at 760 mmHg

Melting Point

350ºC

Flash Point

129.7ºC

Refractive Index

1.816

Water Solubility

0.35 g/L (25 ºC)

Stability

Stable under normal temperatures and pressures.

Storage Condition

Store in a tightly closed container. Store in a cool, dry area away from incompatible substances.

 

 

 

What is  allopurinol  ?

 

Allopurinol is a  xanthine structural isomer of hypoxanthine. Allopurinol inhibits xanthine oxidase, an enzyme that converts oxypurines to uric acid. By blocking the production of uric acid, this agent decreases serum and urine concentrations of uric acid, thereby providing protection against uric acid-mediated end organ damage in conditions associated with excessive production of uric acid, i.e. the massive cell lysis associated with the treatment of some malignancies. (NCI04)

 

Function & Application
 

Allopurinol is a oxidase inhibitor and a widely used medication for gout. Allopurinol is a rare but well known cause of acute liver injury that has features of a hypersensitivity reaction and can be severe and even fatal.

 

Allopurinol is taken as a tablet once a day. It is usually better to take it just after eating and the tablet should be swallowed with water. It is important to drink plenty of water during the day because this will help you get rid of more urate through your kidneys.Your dose of allopurinol may change over time, depending on the amount of urate in your body. Your doctor will monitor your urate levels with blood tests every 2-4 weeks, until they are sure that the dose that you’re taking is high enough to reduce the amount of urate in your body.You may need to remain on a lower dose if you have kidney or liver problems.

Your doctor may recommend that you do not start taking allopurinol until after an attack of gout has passed to avoid triggering further attacks. If this is not possible, it may be started when your inflammation is not too bad.Allopurinol doesn’t treat the immediate pain caused by attacks of gout. But it’s a long-term treatment to get rid of the urate crystals which causes gout attacks. It is likely that you will need to take allopurinol for the rest of your life to manage your urate levels. You should keep taking allopurinol even if: you are experiencing more gout attacks, or it doesn’t seem to help the pain and inflammation at first you stop having gout attacks – stopping your treatment can cause urate crystals to form again, which will lead to more gout attacks.To reduce the effects of gout attacks in the first three to six months of taking allopurinol, your doctor may prescribe a low dose of colchicine or a non-steroidal anti-inflammatory drug (NSAID)​, such as: etoricoxib ketoprofen naproxen .You should be offered another tablet, known as a proton pump inhibitor, to protect your stomach while taking NSAIDs. If you cannot take NSAIDs, colchicine or steroids may be given instead.

1. Adults often take orally. ① Treatment of gout, 0.1g once, 2-3 times a day; Or 0.3g once, once a day; In order to reduce the onset of acute gout, the initial dosage was 0.1g per day, and gradually increased until the serum uric acid concentration approached 6mgJ100ml. The maximum daily dosage should not exceed 0.3g. Because this product metabolite oxypurinol is excreted by the kidney, the dosage of renal insufficiency can be reduced according to the creatinine clearance rate. The daily dosage of creatinine clearance rate is 0.2g when 10 -- 20ml per minute, 0.1g when 3 -- 10ml per minute, 0.1g when less than 3ml per minute, and 0.1g every 24 hours or more. ② Treatment of kidney stones, 0.1 -- 0.2g, 1 -- 4 times a day; Or 0.3g once, once a day.

 

2. Children often take oral dosage. Limited for secondary hyperuricemia of malignant tumors, 50mg once within 6 years old, 3 times a day; From 6 to 10 years old, 100mg once, three times a day, or 300mg once a day. After 48 hours of administration, dosage should be adjusted according to patient response.

 

Folding preparations and specifications

Allopurinol tablets 0.1g

 

(1) For reducing the concentration of uric acid in the blood, orally, 50mg each time,2-3 times a day, the dose increases gradually,2-3 weeks later, up to 0.2-0.4g a day, divided into 2-3 times. Maintenance dose 0.1-0.2g each time, 2-3 times a day. (2) for uric acid calculi, orally 0.1-0.2g each time, 4 times a day, or 300mg once a day.

 

1. Treatment of gout: the initial dose of 0.05g each time, 2-3 times a day, increased to 0.2 ~ 0.4g a day after 2 ~ 3 weeks, divided into 2 ~ 3 times; Severe gout can be used up to 0.6g per day. Children 8mg/kg daily. Maintenance dose: 0.1-0.2g for adults, 2-3 times a day.

 

2. Treatment of secondary hyperuricemia: the general dose is 0.1 ~ 0.6g per day, divided into 2 ~ 3 times. For patients with hyperuricemia and leukemia, the initial dose was 0.2g, 3 times a day. Maintenance dose 0.3-0.4 g per day, divided.

 

3. Treatment of major epilepsy: on the basis of using original antiepileptic drugs, take 0.3g of this product in the afternoon every day (0.15g for children under 10 years old every day).

 

This product can induce acute gout and increase the frequency and severity of acute gout, so it should be combined with low dose colchicine in the first 4 to 8 weeks.

 

Take the period should drink more water, and make urine neutral or alkaline to facilitate uric acid excretion. At the same time, it is advisable to eat a low purine diet, and should be taken after meals to reduce gastric irritation.

 

 

Versus Arthritis Gout Medication Allopurinol Fine Powder Cas 315-30-0 1

 

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