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Properties

What is  allopurinol  ?

Allopurinol is used for the long-term treatment and prevention of gout . Taken regularly, it can stop attacks of gout and help prevent damage to your joints.Gout occurs in people who have high levels of urate in their blood. Every day, the body naturally produces urate. This normally dissolves in your blood until it is passed out of the body, mainly in your pee.But if too much urate is produced, or your body cannot get rid of it properly, urate crystals can form in and around your joints. These crystals can slowly form for years without you knowing. Once many crystals have formed, they can shed into the joint, causing painful inflammation.Allopurinol works by lowering the amount of urate in your blood. Because of this, it’s sometimes called a urate lowering therapy (ULT). Once your urate level is low enough, new crystals will stop forming and existing crystals will slowly dissolve.After a few years, all the crystals may dissolve. If this happens, there will be no more joint damage or gout attacks caused by these crystals, as long as you are taking allopurinol.Because it can take a long time to dissolve the crystals, you may have more attacks of gout while this is happening. This is more likely if your urate levels are very high to begin with, or if you have had gout for a long time.If this happens to you, it does not mean that the allopurinol is not working.

Function & Application
 

Allopurinol is often recommended as the first choice of treatment to control gout. If your doctor prescribes it as soon as you are diagnosed, it may prevent future attacks and joint damage.

You will usually be offered allopurinol if blood tests show that your urate level is high enough for urate crystals to form, especially if one or more of the following applies:

You are having frequent attacks of gout.
your joints have been damaged by gout.
your skin has visible deposits of urate crystals. These are firm white lumps, which are called tophi.
You may not be offered allopurinol, or you may be given a lower dose, if you:

have ever had an allergic reaction to allopurinol.
are currently having an attack of gout.
have problems with your liver or kidneys.
are of Han Chinese, Thai or Korean origin.
have thyroid problems.

Usage and dosage

1. Adults often take orally. ① Treatment of gout, 0.1g once, 2-3 times a day; Or 0.3g once, once a day; In order to reduce the onset of acute gout, the initial dosage was 0.1g per day, and gradually increased until the serum uric acid concentration approached 6mgJ100ml. The maximum daily dosage should not exceed 0.3g. Because this product metabolite oxypurinol is excreted by the kidney, the dosage of renal insufficiency can be reduced according to the creatinine clearance rate. The daily dosage of creatinine clearance rate is 0.2g when 10 -- 20ml per minute, 0.1g when 3 -- 10ml per minute, 0.1g when less than 3ml per minute, and 0.1g every 24 hours or more. ② Treatment of kidney stones, 0.1 -- 0.2g, 1 -- 4 times a day; Or 0.3g once, once a day.

2. Children often take oral dosage. Limited for secondary hyperuricemia of malignant tumors, 50mg once within 6 years old, 3 times a day; From 6 to 10 years old, 100mg once, three times a day, or 300mg once a day. After 48 hours of administration, dosage should be adjusted according to patient response.

Folding preparations and specifications

Allopurinol tablets 0.1g

(1) For reducing the concentration of uric acid in the blood, orally, 50mg each time,2-3 times a day, the dose increases gradually,2-3 weeks later, up to 0.2-0.4g a day, divided into 2-3 times. Maintenance dose 0.1-0.2g each time, 2-3 times a day. (2) for uric acid calculi, orally 0.1-0.2g each time, 4 times a day, or 300mg once a day.

1. Treatment of gout: the initial dose of 0.05g each time, 2-3 times a day, increased to 0.2 ~ 0.4g a day after 2 ~ 3 weeks, divided into 2 ~ 3 times; Severe gout can be used up to 0.6g per day. Children 8mg/kg daily. Maintenance dose: 0.1-0.2g for adults, 2-3 times a day.

2. Treatment of secondary hyperuricemia: the general dose is 0.1 ~ 0.6g per day, divided into 2 ~ 3 times. For patients with hyperuricemia and leukemia, the initial dose was 0.2g, 3 times a day. Maintenance dose 0.3-0.4 g per day, divided.

3. Treatment of major epilepsy: on the basis of using original antiepileptic drugs, take 0.3g of this product in the afternoon every day (0.15g for children under 10 years old every day).

This product can induce acute gout and increase the frequency and severity of acute gout, so it should be combined with low dose colchicine in the first 4 to 8 weeks.

Take the period should drink more water, and make urine neutral or alkaline to facilitate uric acid excretion. At the same time, it is advisable to eat a low purine diet, and should be taken after meals to reduce gastric irritation.