Pharma Pure Powder Strontium Ranelate 99% Cas 135459-87-9 for Osteoporosis Treatment in Postmenopausal Women from Manufacture

Description:
 

Strontium ranelate is a medicine for the treatment of osteoporosis. Its appearance is white to slightly yellow powder or crystalline powder. It is odorless, slightly soluble in water, almost insoluble in ethanol, and easily soluble in dilute hydrochloric acid. It is produced by the French company Servier Researched and developed, first listed in Ireland in November 2004 and listed in the UK in December of the same year.

Clinically, it is mainly used to treat and prevent osteoporosis in postmenopausal women, and significantly reduce the risk of vertebral fractures and hip fractures. Strontium ranelate has the dual pharmacological effects of inhibiting bone resorption and promoting bone formation. On the one hand, osteoblast-enriched cells can increase the synthesis of collagen and non-collagen, and promote osteoblast-mediated bone formation by enhancing the proliferation of pre-osteoblasts.

On the other hand, by reducing osteoclast differentiation and resorption activity, reducing bone resorption, so that bone renewal is rebalanced, which is beneficial to bone formation. Strontium ranelate exerts its pharmacological effects mainly through strontium atoms. Strontium is an alkaline earth metal element of the same family as calcium and is located below calcium in the periodic table. Its absorption, distribution, and excretion are similar to calcium. After oral administration of 2g Chemicalbook. The absolute bioavailability of strontium is 27%.

Large doses of strontium can cause abnormal bone mineral metabolism. Low doses of strontium can enhance the replication of pre-osteoblasts, increase the number of osteoblasts, and stimulate bone formation; at the same time, it can also reduce the activity of osteoclasts and reduce osteoclasts. Quantity, reduce the rate of bone resorption. The results obtained in animal and human studies are in agreement. Osteoporosis (OP) is a progressive bone disease characterized by decreased bone density (BMD) and degenerative changes in the microstructure of bone tissue. It is manifested by increased bone fragility and susceptibility to fractures, the latter being the most common in the spine, hips and wrists. After menopause or after undergoing surgery to remove the ovaries, women stop producing estrog that can keep bones strong.

Therefore, primary OP is especially common in postmenopausal or menopausal women. Currently, there are two types of drugs commonly used to treat osteoporosis: one is drugs that inhibit the activity of osteoclasts to inhibit bone resorption, such as bisphosphonates, calcitonin, etc.; the second is to promote osteoblasts For drugs that are active to stimulate bone formation, only human recombinant parathyroid hormone 1-34 is currently on the market, which requires injection and has a high drug price.

Function and Application

It is mainly used to treat and prevent osteoporosis in postmenopausal women and significantly reduce the risk of vertebral and hip fractures.

Packing:

• Delivery Time: Around 3-5 workdays after your payment.
• Package: In fiber-drums with two-plastic bags inside.
• Net Weight: 25kgs/Drum / Gross Weight: 28kgs/Drum
• Drum Size & Volume: I.D.42cm × H52cm, 0.08 m³/ Drum
• Storage: Stored in dry and cool place, keep away from strong light and heat.
• Shelf Life: Two years when properly stored.

• 1, DHL Express, FEDEX and EMS for quantity less than 50KG, usually called as DDU service;
• 2, Sea shipping for quantity over 500KG; and air shipping is available for 50KG above;
• 3, For high value products, please select air shipping and DHL express for safe;
• 4, Please confirm if you can make the clearance when goods reach your customs before placing an order, for buyers from Mexico, Turkey, Italy, Romania,Russia, and other remote area.

FAQ
 

Q1: How to confirm the Product Quality before placing orders?

A: By sending you our available samples.
Or if you have special requirement on the goods, we can prepare samples according to your requirement for your confirmation.

Q2: Can you supply free samples?

A: Yes, we can provide some free sample, but the shipping cost should be on the customers' account. You can either pay the shipping cost or arrange a courier to collect the samples.

Q3: What's the MOQ?

A: For the high value product, our MOQ starts from 1g and generally starts from 10g.
For other low value product, our MOQ starts from 100g and 1kg.

Q4: How to place order and make payment?

A: You can send our your Purchase order(if your company has), or just send a simple confirmation by email or by TradeManager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.

Q5: How do you treat quality complaint?

A: All our products are strictly tested by our QC, and confirmed by QA; unqualified material will not be released to customer.
In case any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.