Bacterin is widely used in gastrointestinal nematodes, lungworms and parasitic arthropods of cattle, sheep, horses and pigs, intestinal nematodes of dogs, ear mites, scabies, heartworms and microfilariae, as well as gastrointestinal nematodes and ectoparasites of poultry.
(l) Ivermectin for cattle and sheep by 0.2mg/kg orally or subcutaneously; The insecticidal rate was 97-100% against hemocellus, Osteriasis, Gucyperus, Strongyloides trichostrongyloides (including Strongyloides escherichia), rounded nematodes, stomatodes, nematodes, nematodes, nematodes and chabot sheep adults and stage 4 larvae. These doses are also effective on arthropods, such as maggots (cowskin fly, leatherskin fly, rabid fly), mites (bovine scabies, pruritic mite) and lice (bovine palate lice, bovine blood lice and sheep palate lice). Ivermectin is less effective on chewing louse (trichoderma) and sheep tick fly. Ivermectin is also highly effective against ticks and flies that reproduce in their faeces. Although the drug cannot kill or dismember ticks immediately, it can affect feeding, molting and oviposition, thus reducing the reproductive capacity of ticks. The above phenomenon was most obvious in ticks 5 days after a single subcutaneous injection of 0.2mg/kg or daily feeding of low concentration (0.01mg/kg). According to 0.2 mg/kg dose a subcutaneous injection of breeding in the feces of flies also have certain control effect, cattle use 9 days after their faeces plane flies, autumn housefly larvae cannot develop adult, another 5 days, due to the deformity of pupa and adult mature process is inhibited, thus greatly reducing the flies breeding of blood fly (one blood fly) in the dose, similar after 4 weeks.
(2) Internal administration of 0.2mg/kg ivermectin was highly effective (95%-100%) against adults and stage 4 larvae of the following genera of Macrophyllodes and Microphyllodes. For example, large round nematodes (Common round nematodes, Rounded nematodes equis, rounded nematodes apentatus), roundworms (parascaris equis), pinworms (Equis trichoderma), stomach worms (megadodes, Trichoderma), small intestinal nematodes (Trichoderma Ersonii, Rounded nematodes Weyseri), lungworms (nematodes angelica), etc. Although a dose of 0.2mg/kg was also limited for the three kinds of maggots of the horse stomach fly, the microfilariae of the worm onococci that cause skin injury, and the third stage larvae of the stomach nematode, the optimal treatment was a second dose of the above dose one month later.
Of particular significance is that the recommended dose of ivermectin (0.2mg/kg) is about 99% effective in the treatment of mesenteric artery damage caused by the early and the fourth stage larvae of C. elegans in the transitional stage, usually 2 days after the treatment, the symptoms were significantly relieved, and all the symptoms disappeared in about 28 days.
(3) Intramuscular injection of 0.3mg/kg ivermectin showed broad-spectrum insecticidal activity in pigs. Such as ascaris suis, Strongylodes rubiformis, Strongylodes langerii, trichocephalus, oesophageal mouth nematodes, metastrongylodes, and adult and immature nematodes with ententate, the removal rate was 94% ~ 100%, and it was also very effective against trichinella spiralis in intestinal tract (not in muscle). These methods also have good control effect on pig blood louse and pig scabies mite.
(4) dogs and cats abroad have special dosage form (according to 6 ~ 12μg/kg) for the prevention and control of dog filariasis microfilariasis infection, China can try 50μg/kg internal treatment of filariasis microfilariasis infection (adult ineffective). Clinical trials have confirmed that high dose of ivermectin has high efficacy against a variety of canine parasites, such as 50μg/kg subcutaneous injection of C. Canis, C. brasiliensis and C. Canis, 100μg/kg against C. Canis and 200μg/kg against C. Canis adults and larvae of stage IV. The efficacy of 200μg/kg subcutaneous injection was 69%, while that of oral administration was 95%. This product once subcutaneously injected, the dog parasitic in the lungs of capillus aerosinophilus (200μg/kg), Osselle nematode (400μg/kg) also has excellent effect. The efficacy of 200μg/kg to strongyloides faecalis (except for stage 3 larvae) was 95% ~ 100%. Ivermectin is also effective for some arthropod infections in dogs and cats. Subcutaneous injection of 200μg/kg dose in dogs and cats can rule out infection of ear mite, scabies mite and canine pulmonary acaroid mite after two weeks. At 300μg/kg, two doses (2 weeks apart) were also effective against The infection. The best treatment for demodex in dogs is 600μg/kg subcutaneous injection at an interval of 7 days. Use it 5 times.
(5) It is highly effective to take 200 ~ 300μg/kg orally or subcutaneously for the treatment of domestic nematodes such as ascaris gallicoris and closed capillaria as well as the arthropod parasitised by poultry, such as Genicarus mutatus. However, this product has no effect on chicken nematodes.
(6) Reindeer to reindeer Oedemagenatarandi infection, according to the dosage of cattle (200μg/kg) subcutaneous injection can be.
Although ivermectin is only an fda-approved antiparasitic drug, many invitro invitro studies have shown that ivermectin can inhibit the replication of many RNA viruses, These are Dengue, Zika, Yellow fever, West Nile, Chikungunya and Semliki Forest viruses Sindbis Virus, Porcine reproductive and respiratory syndrome Virus.
A paper by Australian scientist Leon Caly et al. (Caly L, et al.2020) has been published in Antiviral Research on 3 April this year. Ivermectin, a sarS-COV-2 suppressor, can reduce viral nucleic acid (RNA) in cells by 5,000 times between two hours and 48 hours after infection. Since ivermectin is listed in the Who Essential Medicine Standard List and is widely used, further clinical studies on its potential benefits to humans are necessary. In fact, as of December 11, there were 43 clinicaltrials registered on clinicaltrials.gov (author's query December 12, 2020).
In the invitro experiment, 5μM ivermectin was added to SARS-COV-2 infected Vero-HSLAM cell cultures in a petri dish. The supernatant and cell precipitates were harvested at day 0 to 3, and the replication of SARS-CoV-2RNA was analyzed by RT-PCR. It was found that 24 hours after treatment with ivermectin, the amount of viral nucleic acid (RNA) invading cells decreased by 99.8%. By 48 hours, compared with the reference, the viral nucleic acid treated with ivermectin was reduced by about 5000 times, indicating that 48 hours after the intervention of ivermectin, all viral material basically disappeared. Because the trials were conducted in vitro, ivermectin was administered at doses 60 or 10 times higher than the serum drug concentrations observed at conventional or maximum doses for the treatment of parasitic diseases such as river blindness. For this reason, some people believe that the dose required for the treatment of COVID-19 with ivermectin cannot reach the dose used in vitro experiments. Therefore, they believe that any efforts to study it are a waste, but it gives the public a false sense of hope, and it is not recommended to use ivermectin to treat COVID-19. Others, citing the current surge in COVID-19 cases or the sense of urgency of hospital withdrawal, say ivermectin can be widely used as long as it is relatively safe, even without rigorous clinical trial data supporting its efficacy against COVID-19.
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