China Pharma Pure Powder manufacturer

Cas 70288-86-7 Pure Ivermectin Powder For Cattles Intestinal Antiparasitic Drug

Product Details:
Place of Origin: Xi'An,China
Brand Name: wango
Certification: USP, BP
Model Number: W-0011
Payment & Shipping Terms:
Minimum Order Quantity: 1kilogram will be sent by Expresses
Price: FOB price 190-240usd/kg ,price can be negotiable freely .
Packaging Details: 1kg with double plastic container inside/Aluminum foil bag ; 25kg with double plastic container inside/Fiber drum outside.Or as your request.
Delivery Time: 3-5 working days
Payment Terms: L/C, T/T, Western Union
Supply Ability: 1000kilogram every month

Detail Information

Function: Antiparasitic Drug Appearence: White Fine Powder
Name: Ivermectin Cas: 70288-86-7
High Light:

Intestinal Pure Ivermectin Powder

,

Pure Ivermectin Powder For Cattles

,

Antiparasitic 70288-86-7

Product Description

Ivermectin 99%  For Cattles Intestinal Antiparasitic Drug Raw Powder USP  grade Cas 70288-86-7 manufacturer for pets and vets and human !

 

 

COA  

 

Product

Ivermectin

 

Testing Item

Standard

Result

Solubility

Partically insoluble in water, freely soluble in methylene chloride, soluble in alcohol

Complies

Identification

Ivermectin

1. IR-Should comply

2. HPLC-Should comply

Complies

Appearance of solution

Solution is clear ≤ BY7

Complies

Specific Optical Rotation

-17° ~ -20°

-18.5°

Related Substance

a).Impurity (1.3<RRT<1.5) ≤ 2.5%

b).Any other specified impurity ≤ 1.0%

c).Any unspecified impurity ≤ 0.20%

d).Total impurities ≤ 5.0%

a). 2.1%

b).A:0.4%,E:0.2%,H:0.1%,J1:0.4%,J2:0.1%, F or I(RRT0.86):0.1%,For I(RRT1.56):0.1%

c).RRT1.11:0.05%

d).3.6%

Ethanol

≤ 5.0%

3.7%

Formamide

≤ 3.0%

2.3%

Heavy Metal

≤ 0.002%

<0.002%

Moisture

≤ 1.0%

0.08%

Sulfated Ash

≤ 0.1%

0.02%

Content (H2B1a+H2B1b)

95.0% ~ 102.0% (Ivermectin)

96.8%

H2B1a/(H2B1a+ H2B1b)

≥ 98.0%

98.2%

 

What is  Ivermectin 99%  ?

 

It was discovered in soil by Japanese microbiologist Satoshi Vougmura in 1973 and it was successfully isolated and cultured in a laboratory, as shown in Figure 2. It was discovered by Satoshi ō mura that the fungus can produce parasitoid compounds. Under the assistance of Merck's proprietary drug screening laboratory, researchers completed the purification and identification of the active ingredients, naming them Avermectins in 1975. William C. Campbell, an American scientist dedicated to parasite research, modified the chemical structure of avermectin to obtain a safer and more efficient ivermectin. In 1981, ivermectin was approved for marketing in animal husbandry, agriculture and aquaculture (trade name: Mectizan). A few years later, ivermectin proved to have potential for human health applications. It was registered in 1987, and patients were soon offered free use as society struggled to control Onchocerciasis, also known as river blindness, which is endemic in poor tropical regions.

Ivermectin has good effect and safety on nematodes, insects, ticks and other parasites when used in small doses. Launched in 1981, it was quickly used in animal husbandry around the world to protect against nematodes and other infections. It was registered for human use in 1987 and was immediately donated for the treatment of onchocerciasis and lymphatic filariasis. Since its launch, the massive drug donation program has helped 1.5 billion people. The latest figures show that around 186 million people worldwide still need treatment each year, and around 112 million have access to drugs, mainly in the African region.

 

Ivermectin has been a huge success for 40 years and is being investigated by various research institutes. Unfortunately, its mechanism of action remains a mystery. Moreover, although parasites in animals quickly developed resistance to ivermectin, no resistance occurred in humans, even among those who had been taking it for 30 years.

 

Application 

 

Bacterin is widely used in gastrointestinal nematodes, lungworms and parasitic arthropods of cattle, sheep, horses and pigs, intestinal nematodes of dogs, ear mites, scabies, heartworms and microfilariae, as well as gastrointestinal nematodes and ectoparasites of poultry.

 

(l) Ivermectin for cattle and sheep by 0.2mg/kg orally or subcutaneously; The insecticidal rate was 97-100% against hemocellus, Osteriasis, Gucyperus, Strongyloides trichostrongyloides (including Strongyloides escherichia), rounded nematodes, stomatodes, nematodes, nematodes, nematodes and chabot sheep adults and stage 4 larvae. These doses are also effective on arthropods, such as maggots (cowskin fly, leatherskin fly, rabid fly), mites (bovine scabies, pruritic mite) and lice (bovine palate lice, bovine blood lice and sheep palate lice). Ivermectin is less effective on chewing louse (trichoderma) and sheep tick fly. Ivermectin is also highly effective against ticks and flies that reproduce in their faeces. Although the drug cannot kill or dismember ticks immediately, it can affect feeding, molting and oviposition, thus reducing the reproductive capacity of ticks. The above phenomenon was most obvious in ticks 5 days after a single subcutaneous injection of 0.2mg/kg or daily feeding of low concentration (0.01mg/kg). According to 0.2 mg/kg dose a subcutaneous injection of breeding in the feces of flies also have certain control effect, cattle use 9 days after their faeces plane flies, autumn housefly larvae cannot develop adult, another 5 days, due to the deformity of pupa and adult mature process is inhibited, thus greatly reducing the flies breeding of blood fly (one blood fly) in the dose, similar after 4 weeks.

 

(2) Internal administration of 0.2mg/kg ivermectin was highly effective (95%-100%) against adults and stage 4 larvae of the following genera of Macrophyllodes and Microphyllodes. For example, large round nematodes (Common round nematodes, Rounded nematodes equis, rounded nematodes apentatus), roundworms (parascaris equis), pinworms (Equis trichoderma), stomach worms (megadodes, Trichoderma), small intestinal nematodes (Trichoderma Ersonii, Rounded nematodes Weyseri), lungworms (nematodes angelica), etc. Although a dose of 0.2mg/kg was also limited for the three kinds of maggots of the horse stomach fly, the microfilariae of the worm onococci that cause skin injury, and the third stage larvae of the stomach nematode, the optimal treatment was a second dose of the above dose one month later.

 

Of particular significance is that the recommended dose of ivermectin (0.2mg/kg) is about 99% effective in the treatment of mesenteric artery damage caused by the early and the fourth stage larvae of C. elegans in the transitional stage, usually 2 days after the treatment, the symptoms were significantly relieved, and all the symptoms disappeared in about 28 days.

 

(3) Intramuscular injection of 0.3mg/kg ivermectin showed broad-spectrum insecticidal activity in pigs. Such as ascaris suis, Strongylodes rubiformis, Strongylodes langerii, trichocephalus, oesophageal mouth nematodes, metastrongylodes, and adult and immature nematodes with ententate, the removal rate was 94% ~ 100%, and it was also very effective against trichinella spiralis in intestinal tract (not in muscle). These methods also have good control effect on pig blood louse and pig scabies mite.

 

(4) dogs and cats abroad have special dosage form (according to 6 ~ 12μg/kg) for the prevention and control of dog filariasis microfilariasis infection, China can try 50μg/kg internal treatment of filariasis microfilariasis infection (adult ineffective). Clinical trials have confirmed that high dose of ivermectin has high efficacy against a variety of canine parasites, such as 50μg/kg subcutaneous injection of C. Canis, C. brasiliensis and C. Canis, 100μg/kg against C. Canis and 200μg/kg against C. Canis adults and larvae of stage IV. The efficacy of 200μg/kg subcutaneous injection was 69%, while that of oral administration was 95%. This product once subcutaneously injected, the dog parasitic in the lungs of capillus aerosinophilus (200μg/kg), Osselle nematode (400μg/kg) also has excellent effect. The efficacy of 200μg/kg to strongyloides faecalis (except for stage 3 larvae) was 95% ~ 100%. Ivermectin is also effective for some arthropod infections in dogs and cats. Subcutaneous injection of 200μg/kg dose in dogs and cats can rule out infection of ear mite, scabies mite and canine pulmonary acaroid mite after two weeks. At 300μg/kg, two doses (2 weeks apart) were also effective against The infection. The best treatment for demodex in dogs is 600μg/kg subcutaneous injection at an interval of 7 days. Use it 5 times.

(5) It is highly effective to take 200 ~ 300μg/kg orally or subcutaneously for the treatment of domestic nematodes such as ascaris gallicoris and closed capillaria as well as the arthropod parasitised by poultry, such as Genicarus mutatus. However, this product has no effect on chicken nematodes.

(6) Reindeer to reindeer Oedemagenatarandi infection, according to the dosage of cattle (200μg/kg) subcutaneous injection can be.

 

Although ivermectin is only an fda-approved antiparasitic drug, many invitro invitro studies have shown that ivermectin can inhibit the replication of many RNA viruses, These are Dengue, Zika, Yellow fever, West Nile, Chikungunya and Semliki Forest viruses Sindbis Virus, Porcine reproductive and respiratory syndrome Virus.

 

A paper by Australian scientist Leon Caly et al. (Caly L, et al.2020) has been published in Antiviral Research on 3 April this year. Ivermectin, a sarS-COV-2 suppressor, can reduce viral nucleic acid (RNA) in cells by 5,000 times between two hours and 48 hours after infection. Since ivermectin is listed in the Who Essential Medicine Standard List and is widely used, further clinical studies on its potential benefits to humans are necessary. In fact, as of December 11, there were 43 clinicaltrials registered on clinicaltrials.gov (author's query December 12, 2020).

 

In the invitro experiment, 5μM ivermectin was added to SARS-COV-2 infected Vero-HSLAM cell cultures in a petri dish. The supernatant and cell precipitates were harvested at day 0 to 3, and the replication of SARS-CoV-2RNA was analyzed by RT-PCR. It was found that 24 hours after treatment with ivermectin, the amount of viral nucleic acid (RNA) invading cells decreased by 99.8%. By 48 hours, compared with the reference, the viral nucleic acid treated with ivermectin was reduced by about 5000 times, indicating that 48 hours after the intervention of ivermectin, all viral material basically disappeared. Because the trials were conducted in vitro, ivermectin was administered at doses 60 or 10 times higher than the serum drug concentrations observed at conventional or maximum doses for the treatment of parasitic diseases such as river blindness. For this reason, some people believe that the dose required for the treatment of COVID-19 with ivermectin cannot reach the dose used in vitro experiments. Therefore, they believe that any efforts to study it are a waste, but it gives the public a false sense of hope, and it is not recommended to use ivermectin to treat COVID-19. Others, citing the current surge in COVID-19 cases or the sense of urgency of hospital withdrawal, say ivermectin can be widely used as long as it is relatively safe, even without rigorous clinical trial data supporting its efficacy against COVID-19.

 

Q1: Are you a manufacturer?

Advanced R&D technology, 250,000 categories chemical reagent are in stock.
Trading products we will serve for you with our ISO supplier system, which lower your purchasing risk to the maximum level extent.
In addition, we provide the customization service of a new compound from lab to bulk manufacturing.

Q2: How to contact with us?
You can contact with us on Made-in-China, the Average Response Time is 0-4h on duty time, <24h on off-duty time.
For each inquiry, our sales will provide the one-on-one service for you.

Q3:Which kind of payment do you accept?


T/T,Westunion,Bitcoin,D/P, L/C and etc.

Q4:How to confirm the Product Quality before placing orders?


1) You can get free samples for some products, just pay the basic cost for us.
2) Also you can send the specification or your request to us, we will customize the products for you.
3) We emphasis that our whole company makes a living with organic chemical and customers, Absolutely no any possibility to sale any fake goods, unqualified goods, it is a shame for us! And None False certificate/lie/illegal thing in our sales motto!


Q5: How do you treat quality complaint?


The customer complaint handling procedures is the key part in Our ISO management system. We will set up an investigation team for your complaint, and make the handling plan and our corrective and preventive measures within a limited time.

Q6: Package


We have standard package, or it can be customized as per your request.

Q7: Shipping


We have R&D and manufactured chemicals for 6 years, we have rich experience on Shipping, Many famous companies cooperated with us stably, we are good at shipping all kinds of chemical products.

 

Cas 70288-86-7 Pure Ivermectin Powder For Cattles Intestinal Antiparasitic Drug 0

 

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