Product Details:
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Place of Origin: | Xi'An,China |
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Brand Name: | wango |
Certification: | USP, BP |
Model Number: | W-0011 |
Payment & Shipping Terms:
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Minimum Order Quantity: | 1kilogram will be sent by Expresses |
Price: | FOB price 190-240usd/kg |
Packaging Details: | 25kilogram /drum |
Delivery Time: | 3-5 working days |
Payment Terms: | L/C, T/T, Western Union |
Supply Ability: | 1000kilogram every month |
Detail Information |
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Function: | Anti-intestinal Parasites | Appearence: | White Fine Powder |
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Name: | Mk933 | Cas: | 70288-86-7 |
Highlight: | Mk 933 Ivermectin White Fine Powder,Wango Mk 933 Ivermectin |
Product Description
Product |
Ivermectin |
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Testing Item |
Standard |
Result |
Solubility |
Partically insoluble in water, freely soluble in methylene chloride, soluble in alcohol |
Complies |
Identification Ivermectin |
1. IR-Should comply 2. HPLC-Should comply |
Complies |
Appearance of solution |
Solution is clear ≤ BY7 |
Complies |
Specific Optical Rotation |
-17° ~ -20° |
-18.5° |
Related Substance |
a).Impurity (1.3<RRT<1.5) ≤ 2.5% b).Any other specified impurity ≤ 1.0% c).Any unspecified impurity ≤ 0.20% d).Total impurities ≤ 5.0% |
a). 2.1% b).A:0.4%,E:0.2%,H:0.1%,J1:0.4%,J2:0.1%, F or I(RRT0.86):0.1%,For I(RRT1.56):0.1% c).RRT1.11:0.05% d).3.6% |
Ethanol |
≤ 5.0% |
3.7% |
Formamide |
≤ 3.0% |
2.3% |
Heavy Metal |
≤ 0.002% |
<0.002% |
Moisture |
≤ 1.0% |
0.08% |
Sulfated Ash |
≤ 0.1% |
0.02% |
Content (H2B1a+H2B1b) |
95.0% ~ 102.0% (Ivermectin) |
96.8% |
H2B1a/(H2B1a+ H2B1b) |
≥ 98.0% |
98.2% |
What the Ivermectin is ?
Ivermectin is a Food and Drug Administration (FDA)-approved antiparasitic drug that is used to treat several neglected tropical diseases, including onchocerciasis, helminthiases, and scabies.1 It is also being evaluated for its potential to reduce the rate of malaria transmission by killing mosquitoes that feed on treated humans and livestock.2 For these indications, ivermectin has been widely used and is generally well tolerated.1,3 Ivermectin is not approved by the FDA for the treatment of any viral infection.
Application
Reports from in vitro studies suggest that ivermectin acts by inhibiting the host importin alpha/beta-1 nuclear transport proteins, which are part of a key intracellular transport process that viruses hijack to enhance infection by suppressing the host’s antiviral response.4,5 In addition, ivermectin docking may interfere with the attachment of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein to the human cell membrane.6 Ivermectin is thought to be a host-directed agent, which may be the basis for its broad-spectrum activity in vitro against the viruses that cause dengue, Zika, HIV, and yellow fever.4,7-9 Despite this in vitro activity, no clinical trials have reported a clinical benefit for ivermectin in patients with these viruses. Some studies of ivermectin have also reported potential anti-inflammatory properties, which have been postulated to be beneficial in people with COVID-19.10-12
Some observational cohorts and clinical trials have evaluated the use of ivermectin for the prevention and treatment of COVID-19. Data from some of these studies .
Recommendation :
There is insufficient evidence for the COVID-19 Treatment Guidelines Panel (the Panel) to recommend either for or against the use of ivermectin for the treatment of COVID-19. Results from adequately powered, well-designed, and well-conducted clinical trials are needed to provide more specific, evidence-based guidance on the role of ivermectin in the treatment of COVID-19.
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