Ivermectin is widely used in gastrointestinal nematodes, lungworms and parasitic arthropods of cattle, sheep, horses and pigs, intestinal nematodes of dogs, ear mites, scabies, heartworms and microfilariae, as well as gastrointestinal nematodes and ectoparasites of poultry.
(l) Ivermectin for cattle and sheep by 0.2mg/kg orally or subcutaneously; The insecticidal rate was 97-100% against hemocellus, Osteriasis, Gucyperus, Strongyloides trichostrongyloides (including Strongyloides escherichia), rounded nematodes, stomatodes, nematodes, nematodes, nematodes and chabot sheep adults and stage 4 larvae. These doses are also effective on arthropods, such as maggots (cowskin fly, leatherskin fly, rabid fly), mites (bovine scabies, pruritic mite) and lice (bovine palate lice, bovine blood lice and sheep palate lice). Ivermectin is less effective on chewing louse (trichoderma) and sheep tick fly.
Ivermectin is also highly effective against ticks and flies that reproduce in their faeces. Although the drug does not kill or dismember ticks immediately, it can affect ticks
Feeding, molting, and laying eggs, thus reducing fertility. Animals were subcutaneously injected 0.2mg/kg at one time or fed low concentrations daily
(0. 01mg/kg) at 5 days after treatment, the above phenomenon was most obvious in ticks. According to 0.2 mg/kg dose a subcutaneous injection of breeding in the feces of flies also have certain control effect, cattle use 9 days after their faeces plane flies, autumn housefly larvae cannot develop adult, another 5 days, due to the deformity of pupa and adult mature process is inhibited, thus greatly reducing the flies breeding of blood fly (one blood fly) in the dose, similar after 4 weeks.
(2) Internal administration of 0.2mg/kg ivermectin was highly effective (95%-100%) against adults and stage 4 larvae of the following genera of Macrophyllodes and Microphyllodes. For example, large round nematodes (Common round nematodes, Rounded nematodes equis, rounded nematodes apentatus), roundworms (parascaris equis), pinworms (Equis trichoderma), stomach worms (megadodes, Trichoderma), small intestinal nematodes (Trichoderma Ersonii, Rounded nematodes Weyseri), lungworms (nematodes angelica), etc. Although a single dose of 0.2 mg/kg is also very limited for the three kinds of maggots of horse stomach flies, the microfilariae of Onococci that cause skin injury, and the third stage larvae of stomach nematode, the optimal treatment is to use the above dose again one month later.
Of particular significance is that the recommended dose of ivermectin (0.2mg/kg) is about 99% effective in the treatment of mesenteric artery damage caused by the early and the fourth stage larvae of C. elegans in the transitional stage, usually 2 days after the treatment, the symptoms were significantly relieved, and all the symptoms disappeared in about 28 days.
(3) Intramuscular injection of 0.3mg/kg ivermectin showed broad-spectrum insecticidal activity in pigs. Such as ascaris suis, Strongylodes rubiformis, Strongylodes langerii, trichocephalus, oesophageal mouth nematodes, metastrongylodes, and adult and immature nematodes with ententate, the removal rate was 94% ~ 100%, and it was also very effective against trichinella spiralis in intestinal tract (not in muscle). These methods also have good control effect on pig blood louse and pig scabies mite.
(4) dogs and cats abroad have special dosage form (according to 6 ~ 12μg/kg) for the prevention and control of dog filariasis microfilariasis infection, China can try 50μg/kg internal treatment of filariasis microfilariasis infection (adult ineffective). Clinical trials have confirmed that high dose of ivermectin has high efficacy against a variety of canine parasites, such as 50μg/kg subcutaneous injection of C. Canis, C. brasiliensis and C. Canis, 100μg/kg against C. Canis and 200μg/kg against C. Canis adults and larvae of stage IV. The efficacy of 200μg/kg subcutaneous injection was 69%, while that of oral administration was 95%. This product is injected subcutaneously once, to the dog parasitic in the lungs of Capillus aerosinophilus (200μg/kg), Osselle nematode (400μg/kg)
It also has excellent exorcism effect. Oral or subcutaneous injection of 200μg/kg, two weeks later, once again, intestinal strongyloides faecalis (no
Except for stage 3 larvae) the effective rate was 95%-100%.
Ivermectin is also effective for some arthropod infections in dogs and cats. Dogs and cats are injected subcutaneously at a dose of 200μg/kg for two weeks
After using again can rule out the infection of ear mite, scabies mite, dog lung prickly mite. 300μg/kg, use twice (interval 2 weeks)
It's also very effective against acaroid mite infection. The best treatment for demodex in dogs is 600μg/kg subcutaneous injection at an interval of 7 days. Use it 5 times.
(5) It is highly effective to take 200 ~ 300μg/kg orally or subcutaneously for the treatment of domestic nematodes such as ascaris gallicoris and closed capillaria as well as the arthropod parasitised by poultry, such as Genicarus mutatus. However, this product has no effect on chicken nematodes.
(6) Reindeer to reindeer Oedemagena tarandi infection, according to the dosage of cattle (200μg/kg) subcutaneous injection can be.
Usage :
The recommended dose for strongyloidosis is a single oral dose of 200 μg/kg, administered with water. Dosing is usually not required, but follow-up is required to ensure a radical cure. The usual dosage is as follows: for 15-24 kg, the dosage is half tablet (about 3 mg); 25-34 kg, 1 tablet (about 6 mg); 35 to 50 kg, dosage is 1 and a half tablets (about 9 mg); 51-65 kg, 2 tablets (about 12 mg); Two and a half tablets (about 15 mg) for patients with 66 to 79 kg; > 80 kg, 200 μg/kg. The recommended dose of onchocerciasis is a single oral dose of 150 μg/kg, administered with water. The usual dosage is as follows: for 15-24 g, the dosage is half tablet (about 3 mg); 25-44 kg, 1 tablet (about 6 mg); The dosage of 45 to 64 kg was 1 and a half tablets (about 9 mg). For 65-84 kg, 2 tablets (about 12 mg); > 80 kg, 150 μg/kg. A single dose of 12 mg (0.2 mg/kg) for ancylostoma infected patients aged 14 years or older; For those under 14 years of age, a single dose of 6 mg was given. A single dose of 6 mg (equivalent to 0.1 mg/kg) was given to patients with ascaris infection over 14 years of age, and 3 mg was given to patients under 14 years of age. A single dose of 12 mg (0.2 mg/kg) for patients over 14 years old infected with whipworm; For those under 14 years of age, a single dose of 6 mg was given. Pinworm infection over 14 years old 12 mg (equivalent to 0.2 mg/kg) orally; For those under 14 years of age, a single dose of 6 mg was given. Overdose: Symptom This product should be used at the prescribed dose. In excess, symptoms may include ataxia, slow breathing, tremor, drooping eyelids, reduced mobility, vomiting, and dilated pupils. Management In case of drug overdose, vomiting and gastric lavage should be carried out as soon as possible, followed by laxative and other conventional antitoxic therapy if necessary. In the event of accidental poisoning, supportive therapy (including fluid and electrolytes replacement, oxygen or mechanical ventilation) may be provided as needed. If clinically obvious hypotension should be given antihypertensive drugs.
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