Valrubicin 99.99% Anti Cancer Supplements Bladder Cancer Treatment 56124-62-0

Product Description

Valrubicin 99.99% Cas 56124-62-0 Bladder Cancer Treatment Raw Material Powder from reseach departments  of China !

Function :

Valrubicin was launched as a new 'chemotherapeutic agent for the treatment of bladder cancer, particularly in patients with BCG-refractory carcinoma in situ (CIS) of the bladder for whom immediate cystectomy is unacceptable. It belongs to the class of anthracyclines, the widest used in human cancers, and is a N-trifluoroacetyl 14-valerate derivative of doxorubicin.

Valrubicin can be obtained in 3 steps from daunomycin by N-trifluoroacetylation of the sugar moiety then iodination of the 2-acetyl group and introduction of a valerate residue. A proposed mechanism involved in the cytotoxicity of Valrubicin coud be the blockade of SV40 large T antigen helicase; this cellular enzyme is involved in the formation of a ternary complex with DNA to maintain the topographic structure of DNA during transcription.

In patients with CIS of bladder refractory to front line and second line therapies, intravesical instillation of Valrubicin resulted in a complete response with a significant rate and allowed a delay in cystectomy. Systemic absorption was minimal and accordingly produced a lower incidence of cardiotoxicity compared with doxorubicin.

Valrubicin is available in 200-mg vials for intravesicular administrationin the treatment of bladder cancer (orphan drugstatus). The increased lipophilicity associated with the valericacid ester and trifluoro acetate functionalities increasestissue penetration and remains intact because, in large measure,of the lack of exposure to hydrolyzing enzymes causedby direct delivery into the bladder followed by voiding ofthe instilled solution. This local action also minimizes cardiotoxicityand other adverse effects seen with other anthracyclines.The major adverse effects that are seen are bladderirritation and reddening of the urine.

How to use it ?

Iv injection: (1) bladder cancer, uterine cancer, urothelial cancer, malignant lymphoma, once every 3 to 4 weeks: 40 ~ 60mg (25 ~ 40mg/m square) (potency), once a day, stop for 3 to 4 weeks, as a course of treatment, repeated application. (2) urothelial carcinoma: use the method twice 3 to 4 weeks, 30 to 40mg (20 to 25mg/m square) (potency), once a day, continuous 2 days, stop 3 to 4 weeks, as a course of treatment, repeated application. (3) Head and neck tumor, breast cancer: once a week, 20 ~ 40mg (14 ~ 25mg/m square) (potency), once a day, 2 ~ 3 times a week, stop for 3 ~ 4 weeks, as a course of treatment, repeated application. (4) Head and neck tumor, malignant lymphoma, daily method, 10 ~ 20mg (7 ~ 14mg/m square) (potency), once a day, continuous use for 3 ~ 5 days, stop for 3 ~ 4 weeks, as a course of treatment, repeated application. (5) Acute leukemia: daily method, 10 ~ 30mg (7 ~ 20mg/m square) (potency), once a day, for 5 days, withdrawal until bone marrow function recovery, repeated application. Intra-arterial injection: for head and neck tumor and bladder cancer, 10 ~ 20mg (7 ~ 14mg/m square) (potency), once a day, 5 ~ 10 times daily or every other day. Intravesical injection: for the treatment of bladder cancer, after urethral catheterization, 15 ~ 30mg (potency) dissolved in 500 ~ 1000μg/ml solution, once a day, 3 times a week, injected into the bladder within 1 ~ 2 hours, as a course of treatment, repeated 2 ~ 3 courses

Why Choose Us?

1. High-concentration products, strictly control the quality.
2. Reasonable and flexible price matched with high quality.
3. Spot samples can be shipped quickly after payment, saving time for receiving goods.
4.Full experience of large numbers containers loading in Chinese sea port.
5. Safe raw materials from China.
6. Have professional customs clearance capabilities and the best after-sales service.

Our Service

1.Cooperate with research institutions, we strictly control the process from raw material to finished product.
2.The customer comes first, we provide reasonable price, high quality product and prompt shipment.
3.We can send the goods to your delivery address directly. It is relatively safe and fast.
4.Quick and clear response to customers questions.
5.We could make our price discount if you place a substantial order with us.
6.Products can be packaged according to customer requirements.

F.A.Q1:Can I get some samples before bulk order?
Most products provide free samples, but the shipping cost be paid by customers.

2: What's your MOQ?

For the high value product, our MOQ starts from 10g,100g and 1kg.

3: Which kind of payment terms do you accept?

PI will be sent first after confirmation of order,enclosed our bank information.Payment by T/T, Western Union, L/C, Alibaba trade assurance, Cashapp,Moneygram or Bitcoin.

4.How to place an order?

You can contact me through Trademanager, WhatsApp, Skype Online and other contact methods, tell me the product and quantity you need, and then we will give you a quote. If you choose one of the above payment methods, we will arrange the delivery for you.

5:How about your delivery time?

A: Generally, it will take 3 to 5 days after receiving your advance payment.

6: How do you treat quality complaint?

A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.